| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Apocalypto | $71,037 | -29.2% | 20 | -3 | $3,551 | $171,575 | 2 | 20th Century Fox International | false | false |
| 2 | - | Music and Lyrics | $60,245 | - | 27 | - | $2,231 | $60,245 | 1 | Warner Bros. | true | false |
| 3 | - | Arthur and the Invisibles | $47,423 | - | 25 | - | $1,896 | $47,423 | 1 | Bazuca Films | true | false |
| 4 | - | Borat | $46,083 | - | 8 | - | $5,760 | $46,083 | 1 | 20th Century Fox International | true | false |
| 5 | 2 | Night at the Museum | $39,866 | -28.3% | 33 | -3 | $1,208 | $1,816,379 | 9 | 20th Century Fox International | false | false |
| 6 | 3 | Norbit | $32,622 | -30.2% | 22 | - | $1,482 | $79,462 | 2 | United International Pictures | false | false |
| 7 | 4 | The Holiday | $31,841 | -26% | 27 | -2 | $1,179 | $229,735 | 4 | United International Pictures | false | false |
| 8 | 5 | Pan's Labyrinth | $26,795 | -21.3% | 6 | - | $4,465 | $165,943 | 4 | Warner Bros. | false | false |
| 9 | 7 | Blood Diamond | $26,028 | -15.9% | 23 | -1 | $1,131 | $433,800 | 7 | Warner Bros. | false | false |
| 10 | 6 | The Departed | $22,009 | -31.9% | 18 | -5 | $1,222 | $910,218 | 18 | Warner Bros. | false | false |
| 11 | 9 | Notes on a Scandal | $19,132 | -20.8% | 5 | - | $3,826 | $72,644 | 3 | 20th Century Fox International | false | false |
| 12 | 8 | Babel | $18,048 | -34.8% | 15 | -6 | $1,203 | $809,677 | 9 | United International Pictures | false | false |
| 13 | 10 | The Pursuit of Happyness | $16,848 | -19.3% | 11 | - | $1,531 | $206,204 | 6 | Sony Pictures Releasing | false | false |
| 14 | 11 | The Illusionist | $16,399 | -20.1% | 13 | -1 | $1,261 | $490,465 | 10 | Transeuropa | false | false |
| 15 | 13 | Letters from Iwo Jima | $10,414 | -34.2% | 8 | -2 | $1,301 | $132,572 | 5 | Warner Bros. | false | false |
| 16 | 14 | The Last King of Scotland | $10,049 | -23.4% | 4 | - | $2,512 | $86,356 | 5 | 20th Century Fox International | false | false |
| 17 | 12 | The Valet | $8,417 | -52.4% | 10 | -4 | $841 | $26,142 | 2 | Transeuropa | false | false |
| 18 | 15 | Little Miss Sunshine | $5,627 | -34.4% | 4 | - | $1,406 | $161,916 | 13 | 20th Century Fox International | false | false |
| 19 | 16 | Flushed Away | $4,698 | -43% | 6 | -6 | $783 | $1,083,412 | 14 | United International Pictures | false | false |
| 20 | 18 | Charlotte's Web | $4,265 | -39.1% | 10 | -3 | $426 | $207,846 | 10 | United International Pictures | false | false |
