| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Apocalypto | $100,267 | - | 23 | - | $4,359 | $100,267 | 1 | 20th Century Fox International | true | false |
| 2 | 1 | Night at the Museum | $55,614 | -36.8% | 36 | -7 | $1,544 | $1,771,742 | 8 | 20th Century Fox International | false | false |
| 3 | - | Norbit | $46,714 | - | 22 | - | $2,123 | $46,714 | 1 | United International Pictures | true | false |
| 4 | 2 | The Holiday | $43,032 | -35% | 29 | -2 | $1,483 | $197,363 | 3 | United International Pictures | false | false |
| 5 | 4 | Pan's Labyrinth | $34,055 | -34.9% | 6 | - | $5,675 | $138,775 | 3 | Warner Bros. | false | false |
| 6 | 3 | The Departed | $32,340 | -39% | 23 | -1 | $1,406 | $885,824 | 17 | Warner Bros. | false | false |
| 7 | 5 | Blood Diamond | $30,939 | -39.3% | 24 | - | $1,289 | $406,677 | 6 | Warner Bros. | false | false |
| 8 | 6 | Babel | $27,691 | -38.3% | 21 | -4 | $1,318 | $789,504 | 8 | United International Pictures | false | false |
| 9 | 8 | Notes on a Scandal | $24,165 | -17.2% | 5 | - | $4,833 | $53,369 | 2 | 20th Century Fox International | false | false |
| 10 | 7 | The Pursuit of Happyness | $20,882 | -37.4% | 11 | - | $1,898 | $188,828 | 5 | Sony Pictures Releasing | false | false |
| 11 | 9 | The Illusionist | $20,526 | -28.1% | 14 | -2 | $1,466 | $472,793 | 9 | Transeuropa | false | false |
| 12 | - | The Valet | $17,677 | - | 14 | - | $1,262 | $17,677 | 1 | Transeuropa | true | false |
| 13 | 10 | Letters from Iwo Jima | $15,815 | -28.9% | 10 | - | $1,581 | $121,831 | 4 | Warner Bros. | false | false |
| 14 | 12 | The Last King of Scotland | $13,125 | -34.1% | 4 | - | $3,281 | $76,102 | 4 | 20th Century Fox International | false | false |
| 15 | 17 | Little Miss Sunshine | $8,584 | -18.1% | 4 | - | $2,146 | $155,870 | 12 | 20th Century Fox International | false | false |
| 16 | 15 | Flushed Away | $8,248 | -36% | 12 | -2 | $687 | $1,075,818 | 13 | United International Pictures | false | false |
| 17 | 14 | Deja Vu | $7,277 | -46.5% | 8 | -4 | $909 | $315,838 | 9 | Buena Vista International | false | false |
| 18 | 16 | Charlotte's Web | $6,999 | -37.1% | 13 | -4 | $538 | $203,034 | 9 | United International Pictures | false | false |
| 19 | 13 | The Tiger and the Snow | $6,714 | -64.8% | 9 | - | $746 | $47,098 | 3 | Bazuca Films | false | false |
| 20 | 20 | Flags of Our Fathers | $5,265 | -25.9% | 7 | - | $752 | $110,306 | 7 | Warner Bros. | false | false |
