| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Night at the Museum | $87,970 | -29.6% | 43 | -4 | $2,045 | $1,714,279 | 7 | 20th Century Fox International | false | false |
| 2 | 2 | The Holiday | $66,251 | -24.9% | 31 | -1 | $2,137 | $154,165 | 2 | United International Pictures | false | false |
| 3 | 15 | The Departed | $52,995 | +233.2% | 24 | +20 | $2,208 | $852,565 | 16 | Warner Bros. | false | false |
| 4 | 5 | Pan's Labyrinth | $52,310 | -0.4% | 6 | - | $8,718 | $104,607 | 2 | Warner Bros. | false | false |
| 5 | 4 | Blood Diamond | $50,942 | -9.1% | 24 | +1 | $2,122 | $375,333 | 5 | Warner Bros. | false | false |
| 6 | 3 | Babel | $44,896 | -26.4% | 25 | -7 | $1,795 | $760,929 | 7 | United International Pictures | false | false |
| 7 | 8 | The Pursuit of Happyness | $33,374 | +2.3% | 11 | - | $3,034 | $167,765 | 4 | Sony Pictures Releasing | false | false |
| 8 | - | Notes on a Scandal | $29,172 | - | 5 | - | $5,834 | $29,172 | 1 | 20th Century Fox International | true | false |
| 9 | 9 | The Illusionist | $28,541 | -7.1% | 16 | - | $1,783 | $451,780 | 8 | Transeuropa | false | false |
| 10 | 7 | Letters from Iwo Jima | $22,228 | -32.3% | 10 | - | $2,222 | $105,901 | 3 | Warner Bros. | false | false |
| 11 | 6 | Rocky Balboa | $20,682 | -48.5% | 27 | -8 | $766 | $271,046 | 4 | 20th Century Fox International | false | false |
| 12 | 12 | The Last King of Scotland | $19,918 | -0.1% | 4 | -1 | $4,979 | $62,909 | 3 | 20th Century Fox International | false | false |
| 13 | 10 | The Tiger and the Snow | $19,073 | -10.7% | 9 | - | $2,119 | $40,340 | 2 | Bazuca Films | false | false |
| 14 | 11 | Deja Vu | $13,599 | -32.1% | 12 | - | $1,133 | $308,329 | 8 | Buena Vista International | false | false |
| 15 | 13 | Flushed Away | $12,881 | -31.2% | 14 | -1 | $920 | $1,066,420 | 12 | United International Pictures | false | false |
| 16 | 14 | Charlotte's Web | $11,130 | -39.6% | 17 | -1 | $654 | $195,824 | 8 | United International Pictures | false | false |
| 17 | 17 | Little Miss Sunshine | $10,481 | +4.5% | 4 | +1 | $2,620 | $147,128 | 11 | 20th Century Fox International | false | false |
| 18 | 19 | Cry Wolf | $9,992 | +48.6% | 9 | +4 | $1,110 | $65,149 | 5 | Bazuca Films | false | false |
| 19 | 16 | Eragon | $7,514 | -36.6% | 6 | -4 | $1,252 | $849,863 | 9 | 20th Century Fox International | false | false |
| 20 | 20 | Flags of Our Fathers | $7,108 | +14.1% | 7 | -1 | $1,015 | $104,928 | 6 | Warner Bros. | false | false |
