| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Night at the Museum | $124,871 | -25.6% | 47 | -7 | $2,656 | $1,632,446 | 6 | 20th Century Fox International | false | false |
| 2 | - | The Holiday | $88,247 | - | 32 | - | $2,757 | $88,247 | 1 | United International Pictures | true | false |
| 3 | 2 | Babel | $60,972 | -26.8% | 32 | - | $1,905 | $718,799 | 6 | United International Pictures | false | false |
| 4 | 3 | Blood Diamond | $56,032 | -25.5% | 23 | - | $2,436 | $325,615 | 4 | Warner Bros. | false | false |
| 5 | - | Pan's Labyrinth | $52,494 | - | 6 | - | $8,749 | $52,494 | 1 | Warner Bros. | true | false |
| 6 | 4 | Rocky Balboa | $40,139 | -44.9% | 35 | -4 | $1,146 | $251,308 | 3 | 20th Century Fox International | false | false |
| 7 | 5 | Letters from Iwo Jima | $32,825 | -35.4% | 10 | - | $3,282 | $83,989 | 2 | Warner Bros. | false | false |
| 8 | 6 | The Pursuit of Happyness | $32,608 | -26.8% | 11 | - | $2,964 | $134,898 | 3 | Sony Pictures Releasing | false | false |
| 9 | 7 | The Illusionist | $30,725 | -22.1% | 16 | +2 | $1,920 | $424,836 | 7 | Transeuropa | false | false |
| 10 | - | The Tiger and the Snow | $21,347 | - | 9 | - | $2,371 | $21,347 | 1 | Bazuca Films | true | false |
| 11 | 8 | Deja Vu | $20,023 | -26.4% | 12 | -1 | $1,668 | $295,742 | 7 | Buena Vista International | false | false |
| 12 | 11 | The Last King of Scotland | $19,941 | -13.5% | 5 | - | $3,988 | $43,154 | 2 | 20th Century Fox International | false | false |
| 13 | 10 | Flushed Away | $18,719 | -26.6% | 15 | -1 | $1,247 | $1,057,515 | 11 | United International Pictures | false | false |
| 14 | 9 | Charlotte's Web | $18,422 | -29.8% | 18 | - | $1,023 | $188,391 | 7 | United International Pictures | false | false |
| 15 | 18 | The Departed | $15,904 | +71.8% | 4 | -1 | $3,976 | $802,588 | 15 | Warner Bros. | false | false |
| 16 | 12 | Eragon | $11,844 | -28% | 10 | -4 | $1,184 | $845,528 | 8 | 20th Century Fox International | false | false |
| 17 | 17 | Little Miss Sunshine | $10,029 | -3.8% | 3 | -1 | $3,343 | $137,163 | 10 | 20th Century Fox International | false | false |
| 18 | 13 | Children of Men | $7,427 | -53.9% | 8 | -6 | $928 | $148,028 | 5 | United International Pictures | false | false |
| 19 | 16 | Cry Wolf | $6,725 | -41.8% | 5 | -4 | $1,345 | $55,364 | 4 | Bazuca Films | false | false |
| 20 | 14 | Flags of Our Fathers | $6,229 | -56.7% | 8 | -2 | $778 | $98,189 | 5 | Warner Bros. | false | false |
