| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Night at the Museum | $344,687 | -31.9% | 73 | -1 | $4,721 | $850,883 | 2 | 20th Century Fox International | false | false |
| 2 | 2 | Babel | $159,629 | -13.6% | 33 | +1 | $4,837 | $344,313 | 2 | United International Pictures | false | false |
| 3 | 4 | The Illusionist | $59,806 | -20.4% | 22 | -1 | $2,718 | $259,600 | 3 | Transeuropa | false | false |
| 4 | - | Children of Men | $58,135 | - | 26 | - | $2,235 | $58,135 | 1 | United International Pictures | true | false |
| 5 | 3 | Eragon | $54,841 | -39.8% | 38 | -7 | $1,443 | $735,127 | 4 | 20th Century Fox International | false | false |
| 6 | 6 | Deja Vu | $45,204 | -17% | 23 | - | $1,965 | $188,387 | 3 | Buena Vista International | false | false |
| 7 | 5 | Flushed Away | $37,851 | -32.6% | 28 | -7 | $1,351 | $947,673 | 7 | United International Pictures | false | false |
| 8 | - | Flags of Our Fathers | $32,870 | - | 10 | - | $3,287 | $32,870 | 1 | Warner Bros. | true | false |
| 9 | 7 | Charlotte's Web | $24,050 | -21.9% | 20 | - | $1,202 | $110,417 | 3 | United International Pictures | false | false |
| 10 | 9 | The Departed | $19,509 | -22.9% | 11 | -2 | $1,773 | $729,782 | 11 | Warner Bros. | false | false |
| 11 | 8 | Marie Antoinette | $18,161 | -32.4% | 4 | - | $4,540 | $81,639 | 3 | Sony Pictures Releasing | false | false |
| 12 | 11 | Saw III | $14,150 | +7.6% | 10 | - | $1,415 | $256,997 | 7 | Buena Vista International | false | false |
| 13 | 10 | Casino Royale | $12,584 | -45.4% | 7 | -9 | $1,797 | $771,639 | 8 | Sony Pictures Releasing | false | false |
| 14 | 12 | Happy Feet | $10,192 | -18.5% | 9 | -5 | $1,132 | $791,044 | 9 | Warner Bros. | false | false |
| 15 | 14 | Little Miss Sunshine | $9,038 | +14% | 4 | - | $2,259 | $89,247 | 6 | 20th Century Fox International | false | false |
| 16 | - | Ask the Dust | $8,642 | - | 7 | - | $1,234 | $8,642 | 1 | Bazuca Films | true | false |
| 17 | 13 | 11:14 | $3,840 | -59.7% | 3 | -2 | $1,280 | $13,374 | 2 | Bazuca Films | false | false |
| 18 | 16 | Live and Become | $2,748 | +4.8% | 1 | - | $2,748 | $29,035 | 6 | Bazuca Films | false | false |
| 19 | 15 | A Movie of Eggs | $2,293 | -69.6% | 4 | -6 | $573 | $43,544 | 3 | Warner Bros. | false | false |
