| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Night at the Museum | $653,632 | -25.2% | 74 | - | $8,832 | $1,522,180 | 2 | 20th Century Fox International | false | false |
| 2 | 2 | Babel | $304,169 | +0.8% | 40 | +4 | $7,604 | $607,834 | 2 | United International Pictures | false | false |
| 3 | 4 | Deja Vu | $199,581 | -12.2% | 53 | +1 | $3,765 | $1,302,669 | 4 | Buena Vista International | false | false |
| 4 | 3 | Flushed Away | $174,004 | -26.6% | 90 | - | $1,933 | $1,328,138 | 4 | United International Pictures | false | false |
| 5 | 5 | The Holiday | $113,251 | -12.1% | 42 | - | $2,696 | $449,891 | 3 | United International Pictures | false | false |
| 6 | - | Charlotte's Web | $108,066 | - | 40 | - | $2,701 | $108,066 | 1 | United International Pictures | true | false |
| 7 | - | Marie Antoinette | $103,708 | - | 14 | - | $7,407 | $103,708 | 1 | Sony Pictures Releasing | true | false |
| 8 | 6 | Eragon | $92,976 | -22.2% | 70 | +10 | $1,328 | $970,599 | 4 | 20th Century Fox International | false | false |
| 9 | - | Flags of Our Fathers | $80,762 | - | 15 | - | $5,384 | $80,762 | 1 | Warner Bros. | true | false |
| 10 | 7 | The Departed | $50,058 | -11% | 47 | -2 | $1,065 | $1,766,702 | 11 | Warner Bros. | false | false |
| 11 | - | Tenacious D in the Pick of Destiny | $47,714 | - | 21 | - | $2,272 | $47,714 | 1 | Distribution Company | true | false |
| 12 | - | Tsotsi | $39,430 | - | 14 | - | $2,816 | $39,430 | 1 | Alfa Films | true | false |
| 13 | 8 | The Grudge 2 | $36,134 | -35.1% | 39 | - | $926 | $174,264 | 3 | Alfa Films | false | false |
| 14 | 9 | Wolf Creek | $23,374 | -41.7% | 24 | - | $973 | $63,230 | 2 | Distribution Company | false | false |
| 15 | 15 | Little Children | $21,922 | -19% | 20 | - | $1,096 | $213,367 | 4 | Distribution Company | false | false |
| 16 | 11 | Casino Royale | $21,413 | -37.7% | 28 | -14 | $764 | $1,347,116 | 8 | Sony Pictures Releasing | false | false |
| 17 | 14 | The Prestige | $21,254 | -28.6% | 27 | -2 | $787 | $682,220 | 9 | Warner Bros. | false | false |
| 18 | 12 | Children of Men | $19,851 | -37.8% | 22 | -2 | $902 | $461,163 | 7 | United International Pictures | false | false |
| 19 | 16 | Pan's Labyrinth | $19,810 | +9.2% | 10 | - | $1,981 | $104,678 | 4 | Warner Bros. | false | false |
| 20 | 13 | Happy Feet | $18,534 | -40.2% | 46 | -15 | $402 | $1,407,699 | 8 | Warner Bros. | false | false |
