| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Night at the Museum | $427,793 | -37% | 88 | - | $4,861 | $2,318,787 | 4 | - | false | false |
| 2 | 2 | The Holiday | $248,541 | -36.8% | 88 | - | $2,824 | $2,573,364 | 6 | United International Pictures | false | false |
| 3 | 3 | Deja Vu | $229,095 | -32.6% | 75 | - | $3,054 | $1,122,294 | 4 | Buena Vista International | false | false |
| 4 | - | The Queen | $189,240 | - | 26 | - | $7,278 | $189,240 | 2 | Filmladen | false | false |
| 5 | 7 | Babel | $152,957 | -12.8% | 20 | - | $7,647 | $749,817 | 5 | Constantin Film | false | false |
| 6 | 4 | The Prestige | $140,174 | -34.6% | 24 | - | $5,840 | $378,753 | 3 | Warner Bros. | false | false |
| 7 | 8 | The Departed | $130,568 | -22.9% | 64 | -1 | $2,040 | $1,886,162 | 7 | Warner Bros. | false | false |
| 8 | 5 | Casino Royale | $108,980 | -42.6% | 54 | -2 | $2,018 | $5,708,157 | 9 | Sony Pictures Releasing | false | false |
| 9 | 6 | Eragon | $85,047 | -52.6% | 79 | -5 | $1,076 | $1,758,883 | 6 | 20th Century Fox International | false | false |
| 10 | 12 | Grave Decisions | $63,585 | +3.9% | 29 | +5 | $2,192 | $584,090 | 10 | Luna Filmverleih | false | false |
| 11 | 11 | Apocalypto | $55,831 | -33.8% | 35 | - | $1,595 | $550,535 | 6 | Constantin Film | false | false |
| 12 | 10 | Flushed Away | $51,989 | -48% | 72 | - | $722 | $1,182,873 | 7 | United International Pictures | false | false |
| 13 | 9 | Happy Feet | $49,904 | -53.4% | 79 | -5 | $631 | $1,596,363 | 8 | Warner Bros. | false | false |
| 14 | - | Just Friends | $32,586 | - | 28 | - | $1,163 | $32,586 | 2 | 3L Filmverleih | false | false |
| 15 | 13 | Hoodwinked! | $31,026 | -39.2% | 36 | - | $861 | $202,491 | 5 | Luna Filmverleih | false | false |
| 16 | 14 | Vitus | $17,377 | -42.4% | 10 | -2 | $1,737 | $127,337 | 5 | Filmladen | false | false |
| 17 | - | Candy | $12,679 | - | 6 | - | $2,113 | $12,679 | 2 | Constantin Film | false | false |
| 18 | - | Shortbus | $12,079 | - | 1 | - | $12,079 | $12,079 | 2 | Stadtkino Filmverleih | false | false |
| 19 | 17 | 7 Dwarves: The Forest Is Not Enough | $10,582 | -41.9% | 32 | -1 | $330 | $3,992,868 | 13 | United International Pictures | false | false |
| 20 | 15 | Open Season | $10,488 | -53.4% | 37 | -6 | $283 | $1,341,875 | 11 | Sony Pictures Releasing | false | false |
