| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Night at the Museum | $874,214 | - | 74 | - | $11,813 | $874,214 | 1 | 20th Century Fox International | true | false |
| 2 | - | Babel | $301,901 | - | 36 | - | $8,386 | $301,901 | 1 | United International Pictures | true | false |
| 3 | 1 | Flushed Away | $237,093 | -34.2% | 90 | - | $2,634 | $1,152,039 | 3 | United International Pictures | false | false |
| 4 | 2 | Deja Vu | $227,268 | -33.8% | 52 | - | $4,370 | $1,110,284 | 3 | Buena Vista International | false | false |
| 5 | 4 | The Holiday | $128,847 | -39.5% | 42 | - | $3,067 | $342,739 | 2 | United International Pictures | false | false |
| 6 | 3 | Eragon | $119,580 | -54% | 60 | +1 | $1,993 | $883,348 | 3 | 20th Century Fox International | false | false |
| 7 | 7 | The Departed | $56,245 | -18.7% | 49 | +1 | $1,147 | $1,727,843 | 10 | Warner Bros. | false | false |
| 8 | 5 | The Grudge 2 | $55,650 | -52.8% | 39 | -1 | $1,426 | $139,032 | 2 | Alfa Films | false | false |
| 9 | - | Wolf Creek | $40,116 | - | 24 | - | $1,671 | $40,116 | 1 | Distribution Company | true | false |
| 10 | - | Breaking and Entering | $35,165 | - | 16 | - | $2,197 | $35,165 | 1 | Buena Vista International | true | false |
| 11 | 6 | Casino Royale | $34,389 | -60.5% | 42 | -44 | $818 | $1,334,352 | 7 | Sony Pictures Releasing | false | false |
| 12 | 11 | Children of Men | $31,927 | -29.7% | 24 | - | $1,330 | $443,789 | 6 | United International Pictures | false | false |
| 13 | 8 | Happy Feet | $30,995 | -55.1% | 61 | -29 | $508 | $1,398,227 | 7 | Warner Bros. | false | false |
| 14 | 10 | The Prestige | $29,763 | -36.3% | 29 | - | $1,026 | $665,278 | 8 | Warner Bros. | false | false |
| 15 | 9 | Little Children | $27,068 | -55.3% | 20 | - | $1,353 | $192,683 | 3 | Distribution Company | false | false |
| 16 | 12 | Pan's Labyrinth | $18,146 | -33.7% | 10 | - | $1,814 | $85,431 | 3 | Warner Bros. | false | false |
| 17 | 13 | The Illusionist | $12,589 | -51.9% | 14 | -5 | $899 | $1,253,688 | 14 | Alfa Films | false | false |
| 18 | 15 | Saw III | $8,928 | -25.8% | 21 | -5 | $425 | $1,063,058 | 12 | Buena Vista International | false | false |
| 19 | 16 | The Secret Life of Words | $8,418 | -21.2% | 9 | -1 | $935 | $121,974 | 7 | 20th Century Fox International | false | false |
| 20 | 17 | The World's Fastest Indian | $5,614 | -42% | 10 | -2 | $561 | $68,696 | 4 | Impacto Cine | false | false |
