| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Night at the Museum | $678,875 | -36.4% | 88 | +3 | $7,714 | $1,903,289 | 3 | - | false | false |
| 2 | 2 | The Holiday | $392,990 | -36% | 88 | -4 | $4,465 | $2,339,939 | 5 | United International Pictures | false | false |
| 3 | 3 | Deja Vu | $340,139 | -28.7% | 75 | +10 | $4,535 | $892,920 | 3 | Buena Vista International | false | false |
| 4 | - | The Prestige | $214,468 | - | 24 | - | $8,936 | $240,130 | 2 | Warner Bros. | false | false |
| 5 | 5 | Casino Royale | $190,009 | -37.1% | 56 | -9 | $3,393 | $5,635,529 | 8 | Sony Pictures Releasing | false | false |
| 6 | 4 | Eragon | $179,371 | -46.8% | 84 | - | $2,135 | $1,684,719 | 5 | 20th Century Fox International | false | false |
| 7 | 6 | Babel | $175,443 | -24.8% | 20 | - | $8,772 | $600,741 | 4 | Constantin Film | false | false |
| 8 | 7 | The Departed | $169,244 | -21.9% | 65 | +3 | $2,603 | $1,767,009 | 6 | Warner Bros. | false | false |
| 9 | 8 | Happy Feet | $107,090 | -48.4% | 84 | -5 | $1,274 | $1,556,536 | 7 | Warner Bros. | false | false |
| 10 | 9 | Flushed Away | $100,061 | -49.1% | 72 | -1 | $1,389 | $1,138,237 | 6 | United International Pictures | false | false |
| 11 | 10 | Apocalypto | $84,341 | -28.3% | 35 | - | $2,409 | $497,921 | 5 | Constantin Film | false | false |
| 12 | 12 | Grave Decisions | $61,178 | -3.1% | 24 | - | $2,549 | $523,890 | 9 | Luna Filmverleih | false | false |
| 13 | 11 | Hoodwinked! | $51,012 | -46.6% | 36 | - | $1,417 | $172,580 | 4 | Luna Filmverleih | false | false |
| 14 | 13 | Vitus | $30,193 | -35.7% | 12 | - | $2,516 | $110,675 | 4 | Filmladen | false | false |
| 15 | 14 | Open Season | $22,483 | -48.3% | 43 | -11 | $522 | $1,340,044 | 10 | Sony Pictures Releasing | false | false |
| 16 | 18 | Borat | $18,938 | -16.4% | 36 | - | $526 | $1,668,607 | 11 | - | false | false |
| 17 | 15 | 7 Dwarves: The Forest Is Not Enough | $18,226 | -53.4% | 33 | -20 | $552 | $4,008,179 | 12 | United International Pictures | false | false |
| 18 | 17 | Carte Blanche/The White Planet | $17,707 | -29.2% | 9 | - | $1,967 | $58,264 | 3 | Constantin Film | false | false |
| 19 | - | Little Miss Sunshine | $16,156 | - | 16 | - | $1,009 | $151,420 | 7 | - | false | false |
| 20 | 20 | The Devil Wears Prada | $11,929 | -32% | 27 | -10 | $441 | $3,558,523 | 14 | - | false | false |
