| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Silent Hill | $20,200,000 | $20,152,598 | -$47,402 | -0.2% | 2,926 | $20,200,000 | $20,152,598 | 1 | Sony Pictures Releasing | - |
| 2 | 2 | - | Scary Movie 4 | $17,034,000 | $16,814,942 | -$219,058 | -1.3% | 3,674 | $67,697,000 | $67,478,181 | 2 | - | - |
| 3 | 3 | - | The Sentinel | $14,650,000 | $14,367,854 | -$282,146 | -1.9% | 2,819 | $14,650,000 | $14,367,854 | 1 | Twentieth Century Fox | - |
| 4 | 4 | - | Ice Age: The Meltdown | $12,800,000 | $13,284,408 | +$484,408 | +3.8% | 3,540 | $167,863,000 | $168,348,135 | 4 | Twentieth Century Fox | - |
| 5 | 5 | - | The Wild | $8,050,000 | $8,332,068 | +$282,068 | +3.5% | 2,854 | $21,958,000 | $22,240,635 | 2 | Walt Disney Studios Motion Pictures | - |
| 6 | 6 | - | The Benchwarmers | $7,300,000 | $7,256,143 | -$43,857 | -0.6% | 3,094 | $47,145,000 | $47,101,418 | 3 | Revolution Studios | - |
| 7 | 7 | - | Take the Lead | $4,250,000 | - | - | - | 2,413 | $29,556,000 | - | 3 | New Line Cinema | - |
| 8 | 9 | +1 | American Dreamz | $3,690,000 | $3,667,420 | -$22,580 | -0.6% | 1,500 | $3,690,000 | $3,667,420 | 1 | Universal Pictures | - |
| 9 | 8 | -1 | Inside Man | $3,668,000 | $3,748,955 | +$80,955 | +2.2% | 2,021 | $81,233,000 | $81,313,510 | 5 | Universal Pictures | - |
| 10 | 10 | - | Friends with Money | $3,551,000 | - | - | - | 991 | $5,333,000 | - | 3 | Sony Pictures Classics | - |
| 11 | 11 | - | Thank You for Smoking | $2,750,000 | $2,780,969 | +$30,969 | +1.1% | 1,020 | $15,750,000 | $15,781,403 | 6 | - | - |
| 12 | 12 | - | Lucky Number Slevin | $2,408,000 | $2,475,903 | +$67,903 | +2.8% | 1,735 | $18,607,000 | $18,674,953 | 3 | - | - |
| 13 | 13 | - | Failure to Launch | $1,440,000 | $1,410,982 | -$29,018 | -2% | 1,295 | $85,634,000 | $85,604,643 | 7 | Paramount Pictures | - |
| 14 | 15 | +1 | My Brother's Wife | $525,000 | $567,671 | +$42,671 | +8.1% | 217 | $1,880,000 | $1,902,664 | 2 | Lionsgate Films | - |
| 15 | 16 | +1 | Phat Girlz | $490,000 | $493,120 | +$3,120 | +0.6% | 444 | $6,354,000 | $6,358,003 | 3 | - | - |
| 16 | 18 | +2 | She's the Man | $419,000 | $413,640 | -$5,360 | -1.3% | 440 | $32,699,000 | $32,694,175 | 6 | DreamWorks | - |
| 17 | 21 | +4 | Larry the Cable Guy: Health Inspector | $230,000 | $267,092 | +$37,092 | +16.1% | 497 | $15,215,000 | $15,252,565 | 5 | Lionsgate Films | - |
| 18 | 22 | +4 | The Shaggy Dog | $215,205 | - | - | - | 319 | $57,192,227 | - | 7 | Walt Disney Studios Motion Pictures | - |
| 19 | 23 | +4 | The Notorious Bettie Page | $195,000 | - | - | - | 52 | $401,000 | - | 2 | Picturehouse | - |
| 20 | 24 | +4 | Brick | $169,000 | - | - | - | 45 | $898,000 | - | 4 | Focus Features | - |
| 21 | 27 | +6 | Tsotsi | $138,000 | $144,531 | +$6,531 | +4.7% | 117 | $2,497,000 | $2,503,137 | 9 | Miramax | - |
| 22 | 31 | +9 | Kinky Boots | $111,000 | - | - | - | 26 | $213,000 | - | 2 | Miramax | - |
| 23 | 35 | +12 | Preaching to the Choir | $100,068 | - | - | - | 100 | $343,522 | - | 2 | Freestyle Releasing | - |
| 24 | 37 | +13 | Madea's Family Reunion | $90,000 | $88,987 | -$1,013 | -1.1% | 145 | $63,233,000 | $63,231,524 | 9 | Lionsgate Films | - |
| 25 | 46 | +21 | When Do We Eat? | $59,300 | $52,652 | -$6,648 | -11.2% | 39 | $370,000 | $362,889 | 3 | THINKFilm | - |
| 26 | 48 | +22 | Hard Candy | $36,000 | $37,802 | +$1,802 | +5% | 2 | $117,000 | $118,832 | 2 | Lionsgate Films | - |
| 27 | 56 | +29 | Mrs. Henderson Presents | $26,200 | $26,508 | +$308 | +1.2% | 53 | $10,893,000 | $10,893,249 | 20 | The Weinstein Company | - |
| 28 | 61 | +33 | On a Clear Day | $23,300 | $23,917 | +$617 | +2.6% | 22 | $136,000 | $136,475 | 3 | Focus Features | - |
| 29 | 67 | +38 | Transamerica | $17,200 | $17,847 | +$647 | +3.8% | 40 | $8,865,000 | $8,865,622 | 21 | The Weinstein Company | - |
