| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Smurfs | $30,596 | -26.3% | 13 | +1 | $2,353 | $411,663 | 5 | Sony Pictures Releasing | false | false |
| 2 | - | Bad Teacher | $15,005 | - | 6 | - | $2,500 | $15,005 | 1 | Sony Pictures Releasing | true | false |
| 3 | - | Cars 2 | $12,079 | - | 11 | - | $1,098 | $13,651 | 1 | Walt Disney Pictures | true | false |
| 4 | 2 | Final Destination 5 | $10,597 | -26% | 10 | - | $1,059 | $38,125 | 2 | Warner Bros. | false | false |
| 5 | 4 | Horrible Bosses | $5,839 | -17.5% | 7 | - | $834 | $65,388 | 4 | Warner Bros. | false | false |
| 6 | 3 | Mr. Popper's Penguins | $5,225 | -34.3% | 8 | +2 | $653 | $41,178 | 3 | 20th Century Fox International | false | false |
| 7 | 6 | Rise of the Planet of the Apes | $2,879 | -35.3% | 6 | - | $479 | $67,605 | 6 | 20th Century Fox International | false | false |
| 8 | 5 | Zookeeper | $2,554 | -55.5% | 9 | -1 | $283 | $25,178 | 3 | Sony Pictures Releasing | false | false |
| 9 | 8 | Harry Potter and the Deathly Hallows: Part 2 | $1,671 | -40.1% | 12 | - | $139 | $292,346 | 9 | Warner Bros. | false | false |
| 10 | 7 | Larry Crowne | $1,523 | -47.2% | 4 | +1 | $380 | $7,602 | 2 | N/A | false | false |
| 11 | 9 | The Hangover Part II | $1,194 | -19.1% | 7 | - | $170 | $334,904 | 16 | Warner Bros. | false | false |
| 12 | - | Rio | $362 | - | 14 | - | $25 | $345,584 | 22 | 20th Century Fox International | false | false |
| 13 | 19 | Transformers: Dark of the Moon | $300 | +248.8% | 11 | - | $27 | $124,026 | 11 | United International Pictures | false | false |
| 14 | 15 | Winnie the Pooh | $271 | -25.5% | 7 | - | $38 | $21,633 | 10 | Walt Disney Pictures | false | false |
| 15 | 10 | Cowboys & Aliens | $265 | -52.1% | 5 | - | $53 | $18,797 | 5 | United International Pictures | false | false |
| 16 | 13 | Kung Fu Panda 2 | $250 | -38.7% | 11 | - | $22 | $193,188 | 15 | United International Pictures | false | false |
| 17 | 16 | Green Lantern | $185 | -36.6% | 7 | - | $26 | $20,146 | 6 | Warner Bros. | false | false |
| 18 | 12 | Pirates of the Caribbean: On Stranger Tides | $168 | -61.4% | 12 | - | $14 | $407,666 | 17 | Walt Disney Pictures | false | false |
| 19 | 20 | Something Borrowed | $109 | +53.5% | 3 | - | $36 | $25,384 | 18 | N/A | false | false |
| 20 | 18 | Bridesmaids | $104 | - | 3 | - | $34 | $42,725 | 12 | United International Pictures | false | false |
| 21 | 14 | Captain America: The First Avenger | $94 | -76.2% | 4 | - | $23 | $32,388 | 7 | United International Pictures | false | false |
| 22 | 11 | The Ages of Love | $61 | -86.7% | 2 | - | $30 | $34,785 | 16 | N/A | false | false |
