| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Pirates of the Caribbean: On Stranger Tides | $900,721 | -20.9% | 99 | -10 | $9,098 | $2,868,693 | 2 | Walt Disney Pictures | false | false |
| 2 | - | The Hangover Part II | $387,664 | - | 62 | - | $6,252 | $387,664 | 1 | Warner Bros. | true | false |
| 3 | 3 | Big Mommas: Like Father, Like Son | $161,651 | -26.6% | 41 | -6 | $3,942 | $927,931 | 3 | 20th Century Fox International | false | false |
| 4 | 2 | Rio | $157,571 | -35.9% | 60 | -9 | $2,626 | $7,884,921 | 8 | 20th Century Fox International | false | false |
| 5 | 4 | Thor | $59,118 | -56.2% | 42 | -21 | $1,407 | $2,553,676 | 5 | United International Pictures | false | false |
| 6 | - | The Crazies | $58,293 | - | 15 | - | $3,886 | $58,293 | 1 | N/A | true | false |
| 7 | 6 | The Switch | $50,693 | -38.8% | 15 | -13 | $3,379 | $399,178 | 3 | N/A | false | false |
| 8 | 5 | Priest | $46,341 | -63.9% | 39 | -20 | $1,188 | $787,028 | 3 | Sony Pictures Releasing | false | false |
| 9 | 8 | Gnomeo & Juliet | $32,722 | -30.6% | 25 | -6 | $1,308 | $429,899 | 4 | N/A | false | false |
| 10 | - | Beyond a Reasonable Doubt | $32,508 | - | 15 | - | $2,167 | $32,508 | 1 | N/A | true | false |
| 11 | 7 | Love & Other Drugs | $15,557 | -69.2% | 9 | -11 | $1,728 | $103,578 | 2 | 20th Century Fox International | false | false |
| 12 | 9 | Just Go with It | $12,651 | -69.7% | 12 | -11 | $1,054 | $2,794,503 | 7 | Sony Pictures Releasing | false | false |
| 13 | 10 | El último cuerpo | $11,958 | -52.3% | 16 | -8 | $747 | $84,921 | 3 | N/A | false | false |
| 14 | 11 | The Rebound | $10,479 | -32.6% | 5 | -1 | $2,095 | $56,133 | 3 | N/A | false | false |
| 15 | 12 | Biutiful | $8,907 | -15.3% | 3 | -1 | $2,969 | $26,490 | 2 | N/A | false | false |
| 16 | 13 | Hop | $3,632 | -43.9% | 7 | -13 | $518 | $1,322,862 | 7 | United International Pictures | false | false |
| 17 | 14 | Hall Pass | $2,614 | -53.6% | 2 | -1 | $1,307 | $1,106,944 | 9 | Warner Bros. | false | false |
| 18 | 16 | Mother and Child | $1,456 | -51% | 1 | -1 | $1,456 | $32,401 | 4 | N/A | false | false |
| 19 | 22 | African Cats | $936 | +135.8% | 3 | +1 | $312 | $39,586 | 6 | Walt Disney Pictures | false | false |
| 20 | 15 | 127 Hours | $918 | -80.7% | 1 | -6 | $918 | $48,330 | 3 | 20th Century Fox International | false | false |
| 21 | 21 | A Turtle's Tale: Sammy's Adventures | $800 | -9.7% | 4 | - | $200 | $612,946 | 10 | N/A | false | false |
| 22 | 18 | The Ghost Writer | $428 | -80.3% | 1 | - | $428 | $66,393 | 5 | N/A | false | false |
| 23 | 20 | Black Swan | $129 | -90% | 1 | -1 | $129 | $428,095 | 6 | 20th Century Fox International | false | false |
