| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Harry Potter and the Deathly Hallows: Part 1 | $351,565 | -39% | 125 | +6 | $2,812 | $2,788,955 | 3 | Warner Bros. | false | false |
| 2 | 2 | Megamind | $239,317 | +13.4% | 90 | - | $2,659 | $535,329 | 2 | United International Pictures | false | false |
| 3 | 3 | The Last Exorcism | $56,774 | -29.1% | 23 | +3 | $2,468 | $176,216 | 2 | Andes Films | false | false |
| 4 | - | Killers | $34,138 | - | 18 | - | $1,896 | $41,696 | 1 | N/A | true | false |
| 5 | - | The Other Guys | $33,126 | - | 27 | - | $1,226 | $33,126 | 1 | Sony Pictures Releasing | true | false |
| 6 | 4 | Paranormal Activity 2 | $29,413 | -42% | 26 | -6 | $1,131 | $854,498 | 5 | United International Pictures | false | false |
| 7 | 5 | Post Mortem | $18,726 | -55.3% | 23 | +2 | $814 | $81,651 | 2 | N/A | false | false |
| 8 | 6 | Never Let Me Go | $14,033 | -47.7% | 9 | - | $1,559 | $52,377 | 2 | 20th Century Fox International | false | false |
| 9 | - | The Kids Are All Right | $12,118 | - | 6 | - | $2,019 | $12,118 | 1 | Transeuropa | true | false |
| 10 | 7 | Due Date | $11,309 | -45.7% | 11 | -5 | $1,028 | $279,577 | 5 | Warner Bros. | false | false |
| 11 | 9 | The Social Network | $7,479 | -31.9% | 8 | -3 | $934 | $272,775 | 6 | Sony Pictures Releasing | false | false |
| 12 | 8 | Eat Pray Love | $7,037 | -36.5% | 6 | - | $1,172 | $423,822 | 8 | Sony Pictures Releasing | false | false |
| 13 | 15 | Life as We Know It | $2,790 | +176.8% | 5 | +3 | $558 | $228,355 | 7 | Warner Bros. | false | false |
| 14 | 13 | Saw 3D | $1,291 | -36.8% | 2 | -1 | $645 | $682,059 | 6 | N/A | false | false |
| 15 | 11 | RED | $1,038 | -58% | 2 | - | $519 | $131,752 | 5 | N/A | false | false |
| 16 | 14 | The Girl Who Played with Fire | $539 | -59.3% | 2 | - | $269 | $34,199 | 4 | Andes Films | false | false |
| 17 | 16 | The Town | $520 | -28.6% | 2 | +1 | $260 | $152,478 | 6 | Warner Bros. | false | false |
| 18 | 12 | Qué pena tu vida | $444 | -79.8% | 1 | -1 | $444 | $455,661 | 7 | N/A | false | false |
