| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Eat Pray Love | $193,266 | -21.2% | 84 | +3 | $2,300 | $1,161,982 | 3 | Sony Pictures Releasing | false | false |
| 2 | 1 | Despicable Me | $188,571 | -29.4% | 86 | - | $2,192 | $1,562,938 | 4 | United International Pictures | false | false |
| 3 | - | Alpha and Omega | $125,147 | - | 53 | - | $2,361 | $125,147 | 1 | NuMetro Distribution | true | false |
| 4 | 3 | The Switch | $107,508 | -10.3% | 37 | +1 | $2,905 | $282,301 | 2 | NuMetro Distribution | false | false |
| 5 | - | Charlie St. Cloud | $89,901 | - | 45 | - | $1,997 | $89,901 | 1 | United International Pictures | true | false |
| 6 | 4 | The Other Guys | $85,879 | +8.7% | 51 | - | $1,683 | $929,688 | 5 | Sony Pictures Releasing | false | false |
| 7 | 5 | The Karate Kid | $57,583 | -25.9% | 61 | -16 | $943 | $1,706,111 | 6 | Sony Pictures Releasing | false | false |
| 8 | 6 | Why Did I Get Married Too? | $41,835 | -24.9% | 30 | -7 | $1,394 | $433,505 | 4 | Ster-Kinekor Pictures | false | false |
| 9 | 8 | The Girl with the Dragon Tattoo | $39,374 | -2.3% | 15 | - | $2,624 | $98,665 | 2 | NuMetro Distribution | false | false |
| 10 | - | The Joneses | $38,961 | - | 20 | - | $1,948 | $38,961 | 1 | Ster-Kinekor Pictures | true | false |
| 11 | 7 | Centurion | $35,869 | -12.2% | 25 | - | $1,434 | $98,159 | 2 | Ster-Kinekor Pictures | false | false |
| 12 | - | Machete | $27,273 | - | 20 | - | $1,363 | $27,186 | 1 | Sony Pictures Releasing | true | false |
| 13 | 12 | Wall Street: Money Never Sleeps | $22,667 | -4.2% | 23 | -4 | $985 | $386,642 | 5 | 20th Century Fox International | false | false |
| 14 | 11 | Tinker Bell and the Great Fairy Rescue | $19,247 | -18.7% | 19 | -3 | $1,013 | $47,786 | 2 | Ster-Kinekor Pictures | false | false |
| 15 | 9 | The Last Airbender | $16,600 | -54.3% | 32 | - | $518 | $1,316,709 | 7 | United International Pictures | false | false |
| 16 | 14 | Susanna van Biljon | $11,710 | -17.3% | 13 | -3 | $900 | $184,270 | 5 | N/A | false | false |
| 17 | 18 | Mao's Last Dancer | $9,677 | +13.5% | 9 | -1 | $1,075 | $420,129 | 12 | NuMetro Distribution | false | false |
| 18 | 15 | Step Up 3D | $7,894 | -43.5% | 10 | -11 | $789 | $3,040,681 | 11 | NuMetro Distribution | false | false |
| 19 | - | The End of the Line 2010 Re-release | $4,035 | - | 6 | - | $672 | $4,035 | 1 | United International Pictures | true | false |
| 20 | 20 | London River 2010 Re-release | $682 | +43.6% | 1 | - | $682 | $54,308 | 10 | United International Pictures | false | false |
