| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Saw 3D | $422,116 | - | 69 | - | $6,117 | $422,116 | 1 | N/A | true | false |
| 2 | - | RED | $232,618 | - | 49 | - | $4,747 | $232,618 | 1 | Alfa Films | true | false |
| 3 | 1 | Resident Evil: Afterlife | $148,570 | -56.4% | 68 | -29 | $2,184 | $1,180,367 | 3 | Sony Pictures Releasing | false | false |
| 4 | 2 | The Town | $132,687 | -33.3% | 44 | -1 | $3,015 | $384,358 | 2 | Warner Bros. | false | false |
| 5 | 3 | The Social Network | $125,639 | -30.1% | 51 | - | $2,463 | $352,278 | 2 | Sony Pictures Releasing | false | false |
| 6 | 5 | Life as We Know It | $68,459 | -15.7% | 40 | -3 | $1,711 | $505,706 | 4 | Warner Bros. | false | false |
| 7 | 7 | Gaturro | $66,863 | -10% | 50 | -6 | $1,337 | $1,947,273 | 8 | Distribution Company | false | false |
| 8 | 6 | Eat Pray Love | $59,599 | -22% | 52 | -1 | $1,146 | $1,264,844 | 7 | Sony Pictures Releasing | false | false |
| 9 | 4 | Buried | $47,698 | -44.9% | 34 | -7 | $1,402 | $572,599 | 4 | N/A | false | false |
| 10 | 9 | Legend of the Guardians: The Owls of Ga'Hoole | $47,548 | -21.7% | 48 | -6 | $990 | $937,284 | 5 | Warner Bros. | false | false |
| 11 | 8 | The American | $37,985 | -38.7% | 35 | +1 | $1,085 | $244,574 | 3 | Universal Pictures International (UPI) | false | false |
| 12 | 10 | The Spy Next Door 2010 Re-release | $33,468 | -18.1% | 21 | -1 | $1,593 | $82,629 | 2 | N/A | false | false |
| 13 | - | The Missing Lynx 2010 Re-release | $25,393 | - | 17 | - | $1,493 | $25,393 | 1 | CDI Films | true | false |
| 14 | 11 | No Return | $24,891 | -35% | 41 | -12 | $607 | $514,047 | 5 | Distribution Company | false | false |
| 15 | 14 | Charlie St. Cloud | $19,234 | -37% | 32 | -2 | $601 | $218,369 | 4 | Universal Pictures International (UPI) | false | false |
| 16 | 13 | The Last Exorcism | $18,877 | -40.1% | 30 | -6 | $629 | $1,102,557 | 8 | N/A | false | false |
| 17 | 12 | The Kids Are All Right | $15,389 | -52.1% | 23 | -6 | $669 | $362,097 | 5 | Alfa Films | false | false |
| 18 | 15 | I Love You Phillip Morris | $12,143 | -45.4% | 25 | - | $485 | $331,412 | 6 | N/A | false | false |
| 19 | 16 | The First Day of the Rest of Your Life | $11,180 | -41.1% | 10 | - | $1,118 | $34,351 | 2 | Impacto Cine | false | false |
| 20 | 19 | Tinker Bell and the Great Fairy Rescue | $10,782 | -26.8% | 35 | -4 | $308 | $640,080 | 9 | Walt Disney Pictures | false | false |
| 21 | 23 | The Man Next Door | $9,261 | -1.3% | 8 | -5 | $1,157 | $502,010 | 9 | Primer Plano Film Group | false | false |
| 22 | 17 | Wall Street: Money Never Sleeps | $8,025 | -53.9% | 38 | -9 | $211 | $526,622 | 6 | 20th Century Fox International | false | false |
| 23 | - | Amreeka | $6,877 | - | 6 | - | $1,146 | $6,877 | 1 | IFA | true | false |
| 24 | 20 | Che: A New Man | $6,584 | -49.7% | 8 | -5 | $823 | $90,409 | 4 | Distribution Company | false | false |
| 25 | - | A Rational Solution | $6,013 | - | 4 | - | $1,503 | $6,013 | 1 | Primer Plano Film Group | true | false |
| 26 | 18 | Avatar 2010 Special Edition | $4,142 | -75% | 4 | -11 | $1,035 | $416,278 | 6 | 20th Century Fox International | false | false |
| 27 | 25 | Cats & Dogs: The Revenge of Kitty Galore | $3,865 | +6.3% | 5 | -2 | $773 | $1,417,919 | 11 | Warner Bros. | false | false |
| 28 | 22 | Inception | $3,249 | -70.9% | 4 | -7 | $812 | $5,051,840 | 14 | Warner Bros. | false | false |
| 29 | 24 | Everlasting Moments 2010 Re-release | $2,888 | -24.8% | 3 | -1 | $962 | $26,553 | 4 | Alfa Films | false | false |
| 30 | - | Babies | $2,443 | - | 5 | - | $488 | $2,443 | 1 | Distribution Company | true | false |
| 31 | 21 | Lengua materna | $2,389 | -81.7% | 10 | -7 | $238 | $18,752 | 2 | Distribution Company | false | false |
| 32 | 28 | Going the Distance | $1,679 | +3.9% | 4 | -7 | $419 | $315,755 | 9 | Warner Bros. | false | false |
| 33 | 29 | The Last Airbender | $1,006 | -31.6% | 2 | -3 | $503 | $2,758,319 | 12 | Paramount Pictures International | false | false |
| 34 | 34 | The Dancer and the Thief | $801 | +1% | 4 | -4 | $200 | $261,734 | 8 | Walt Disney Pictures | false | false |
| 35 | 27 | Giant | $741 | -63.9% | 2 | -4 | $370 | $16,272 | 3 | Primer Plano Film Group | false | false |
| 36 | 32 | Despicable Me | $627 | -37% | 2 | -1 | $313 | $2,873,889 | 14 | Universal Pictures International (UPI) | false | false |
| 37 | 31 | The Hedgehog | $323 | -68.8% | 1 | -1 | $323 | $87,888 | 9 | Impacto Cine | false | false |
| 38 | 35 | Igualita a mí | $190 | -67.3% | 1 | -6 | $190 | $3,539,668 | 12 | Walt Disney Pictures | false | false |
| 39 | 36 | The Descent: Part 2 | $180 | -68.7% | 6 | -6 | $30 | $82,547 | 6 | CDI Films | false | false |
| 40 | 33 | Solitary Man | $127 | -85.3% | 3 | -3 | $42 | $227,969 | 10 | Distribution Company | false | false |
| 41 | 39 | Yuki and Nina | $101 | -29.4% | 2 | +1 | $50 | $24,500 | 6 | N/A | false | false |
