| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Town | $53,260 | - | 8 | - | $6,657 | $53,260 | 1 | Warner Bros. | true | false |
| 2 | 2 | Despicable Me | $34,599 | -2.2% | 7 | -1 | $4,942 | $268,803 | 5 | United International Pictures | false | false |
| 3 | 1 | Eat Pray Love | $28,569 | -33.4% | 7 | - | $4,081 | $164,809 | 3 | Sony Pictures Releasing | false | false |
| 4 | - | Devil | $19,624 | - | 6 | - | $3,270 | $19,624 | 1 | United International Pictures | true | false |
| 5 | - | Shanghai | $9,189 | - | 6 | - | $1,531 | $9,189 | 1 | Italian International Film | true | false |
| 6 | 6 | Step Up 3D | $8,884 | -33.3% | 3 | -3 | $2,961 | $517,313 | 7 | Jaguar Film International Distribution | false | false |
| 7 | 3 | Resident Evil: Afterlife | $8,179 | -68% | 5 | -2 | $1,635 | $190,105 | 4 | Jaguar Film International Distribution | false | false |
| 8 | 8 | Wall Street: Money Never Sleeps | $7,435 | -21.7% | 5 | - | $1,487 | $97,275 | 5 | 20th Century Fox International | false | false |
| 9 | 4 | Legend of the Guardians: The Owls of Ga'Hoole | $6,552 | -62% | 5 | -3 | $1,310 | $26,412 | 2 | Warner Bros. | false | false |
| 10 | 5 | Centurion | $5,354 | -62.8% | 6 | +1 | $892 | $23,924 | 2 | N/A | false | false |
| 11 | - | Yanoosak | $3,625 | - | 3 | - | $1,208 | $3,625 | 1 | Italian International Film | true | false |
| 12 | 7 | Going the Distance | $3,498 | -71% | 3 | -2 | $1,166 | $64,482 | 4 | Warner Bros. | false | false |
| 13 | 9 | The Other Guys | $3,481 | -62.4% | 4 | - | $870 | $113,221 | 6 | Sony Pictures Releasing | false | false |
| 14 | 11 | Cyrus | $2,580 | -53.5% | 3 | - | $860 | $10,039 | 2 | 20th Century Fox International | false | false |
| 15 | 14 | You Again | $1,243 | -38% | 2 | -1 | $621 | $31,960 | 5 | Walt Disney Pictures | false | false |
| 16 | 16 | Knight and Day 2010 Re-release | $1,224 | -37.9% | 2 | - | $612 | $271,460 | 17 | 20th Century Fox International | false | false |
| 17 | 12 | Dinner for Schmucks | $1,129 | -61.8% | 1 | -2 | $1,129 | $109,352 | 6 | United International Pictures | false | false |
| 18 | 15 | 12 Angry Lebanese: The Documentary | $900 | -54.6% | 1 | -1 | $900 | $26,118 | 8 | N/A | false | false |
| 19 | 10 | The American | $866 | -88.6% | 3 | -2 | $288 | $47,900 | 4 | Italian International Film | false | false |
| 20 | 18 | Everyday Is a Holiday | $750 | -27.7% | 2 | - | $375 | $8,591 | 4 | N/A | false | false |
| 21 | 22 | Inception | $606 | -11.7% | 1 | - | $606 | $557,224 | 13 | Warner Bros. | false | false |
| 22 | 21 | Cats & Dogs: The Revenge of Kitty Galore | $504 | -26.7% | 1 | - | $504 | $108,350 | 7 | Warner Bros. | false | false |
| 23 | 24 | Lembi 8 Giga | $479 | +49.7% | 1 | - | $479 | $214,228 | 14 | N/A | false | false |
| 24 | 23 | The Sorcerer's Apprentice | $447 | +20.2% | 1 | - | $447 | $191,951 | 15 | Walt Disney Pictures | false | false |
| 25 | 19 | The Descent: Part 2 | $359 | -64.9% | 1 | -2 | $359 | $5,970 | 3 | N/A | false | false |
| 26 | 17 | The Expendables | $201 | -83.5% | 2 | -1 | $100 | $182,018 | 7 | N/A | false | false |
