| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Despicable Me | $5,861,689 | - | 522 | - | $11,229 | $5,861,689 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | - | The Social Network | $3,977,435 | - | 394 | - | $10,095 | $3,977,435 | 1 | Sony Pictures Releasing | true | false |
| 3 | - | Vampires Suck | $1,742,552 | - | 361 | - | $4,827 | $1,742,552 | 1 | 20th Century Fox International | true | false |
| 4 | 1 | Wall Street: Money Never Sleeps | $1,080,636 | -62.1% | 442 | -2 | $2,444 | $4,933,306 | 2 | 20th Century Fox International | false | false |
| 5 | 2 | Life as We Know It | $998,763 | -36.5% | 393 | -2 | $2,541 | $3,619,941 | 2 | Warner Bros. | false | false |
| 6 | 5 | The Town | $549,669 | -40.9% | 253 | -73 | $2,172 | $7,111,429 | 4 | Warner Bros. | false | false |
| 7 | 7 | Made in Dagenham | $549,032 | -32.2% | 316 | -41 | $1,737 | $4,105,167 | 3 | Paramount Pictures International | false | false |
| 8 | 4 | The Other Guys | $531,183 | -47.8% | 316 | -84 | $1,680 | $12,453,556 | 5 | Sony Pictures Releasing | false | false |
| 9 | 3 | Charlie St. Cloud | $503,684 | -51% | 381 | +5 | $1,322 | $2,078,312 | 2 | Universal Pictures International (UPI) | false | false |
| 10 | 8 | Eat Pray Love | $245,187 | -62% | 177 | -211 | $1,385 | $6,864,546 | 4 | Sony Pictures Releasing | false | false |
| 11 | 11 | Mr. Nice | $215,705 | -43.7% | 107 | +5 | $2,015 | $845,465 | 2 | Entertainment One | false | false |
| 12 | 9 | Buried | $198,607 | -62% | 189 | -94 | $1,050 | $2,996,630 | 3 | Icon Film Distribution | false | false |
| 13 | 6 | The Hole | $172,515 | -78.7% | 171 | -154 | $1,008 | $4,499,067 | 4 | N/A | false | false |
| 14 | 10 | Toy Story 3 | $133,506 | -68% | 230 | -169 | $580 | $117,421,878 | 13 | Walt Disney Pictures | false | false |
| 15 | 12 | Marmaduke | $107,477 | -67.2% | 312 | -55 | $344 | $8,721,117 | 9 | 20th Century Fox International | false | false |
