| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Piranha 3D | $284,148 | - | 94 | - | $3,022 | $284,148 | 1 | Cineplex | true | false |
| 2 | 1 | Legend of the Guardians: The Owls of Ga'Hoole | $143,811 | -60.9% | 125 | -18 | $1,150 | $2,230,564 | 4 | Warner Bros. | false | false |
| 3 | 2 | The Town | $89,387 | -31.9% | 47 | +1 | $1,901 | $293,866 | 2 | Warner Bros. | false | false |
| 4 | 3 | Eat Pray Love | $84,570 | -26.4% | 25 | - | $3,382 | $645,422 | 4 | Sony Pictures Releasing | false | false |
| 5 | 5 | Tinker Bell and the Great Fairy Rescue | $44,976 | -46.1% | 42 | +3 | $1,070 | $348,341 | 3 | Walt Disney Pictures | false | false |
| 6 | 7 | The Collector | $38,790 | -37.1% | 26 | - | $1,491 | $144,603 | 2 | Venus | false | false |
| 7 | 6 | Resident Evil: Afterlife | $21,336 | -68.3% | 24 | -22 | $889 | $3,110,026 | 7 | Sony Pictures Releasing | false | false |
| 8 | 4 | Avatar 2010 Special Edition | $20,071 | -77.3% | 18 | -22 | $1,115 | $364,109 | 3 | 20th Century Fox International | false | false |
| 9 | 9 | Wall Street: Money Never Sleeps | $19,556 | -49.5% | 19 | -14 | $1,029 | $459,108 | 5 | 20th Century Fox International | false | false |
| 10 | 8 | Takers 2010 Re-release | $19,177 | -65.9% | 30 | - | $639 | $107,427 | 2 | Sony Pictures Releasing | false | false |
| 11 | 10 | Inception | $18,511 | -44.7% | 12 | -4 | $1,542 | $3,198,883 | 12 | Warner Bros. | false | false |
| 12 | 12 | Vampires Suck | $9,707 | -55.9% | 10 | -5 | $970 | $243,277 | 8 | 20th Century Fox International | false | false |
| 13 | 11 | The Last Airbender | $8,135 | -69% | 32 | -7 | $254 | $3,481,413 | 9 | United International Pictures | false | false |
| 14 | 18 | Micmacs | $6,646 | -0.8% | 10 | - | $664 | $38,957 | 3 | Sony Pictures Releasing | false | false |
| 15 | 13 | Cats & Dogs: The Revenge of Kitty Galore | $6,555 | -65.6% | 30 | -1 | $218 | $2,130,342 | 11 | Warner Bros. | false | false |
| 16 | 14 | From Paris with Love | $6,480 | -54.7% | 11 | -5 | $589 | $174,896 | 6 | - | false | false |
| 17 | 16 | Grown Ups | $6,386 | -26.2% | 6 | - | $1,064 | $983,324 | 12 | Sony Pictures Releasing | false | false |
| 18 | 15 | Despicable Me | $6,101 | -48.7% | 33 | +6 | $184 | $2,802,850 | 13 | Universal Pictures International (UPI) | false | false |
| 19 | 20 | Oceans | $4,313 | -19.5% | 13 | - | $331 | $558,938 | 10 | Cine Colombia | false | false |
| 20 | 21 | The Box | $4,282 | +8.5% | 7 | +3 | $611 | $83,232 | 6 | Cine Colombia | false | false |
| 21 | 17 | Going the Distance | $2,157 | -73% | 5 | -5 | $431 | $311,847 | 6 | Warner Bros. | false | false |
| 22 | 19 | Daybreakers | $2,048 | -62.9% | 3 | -2 | $682 | $1,329,947 | 8 | Venus | false | false |
| 23 | 23 | Halloween II | $1,553 | -27% | 5 | - | $310 | $119,836 | 9 | Cine Colombia | false | false |
| 24 | 22 | The Burning Plain | $1,446 | -61.2% | 4 | -2 | $361 | $63,060 | 6 | Cine Colombia | false | false |
| 25 | 24 | Shrek Forever After | $677 | -58.1% | 3 | -3 | $225 | $6,844,193 | 16 | United International Pictures | false | false |
