| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | The Social Network | $15,500,000 | $15,451,991 | -$48,009 | -0.3% | 2,771 | $46,069,000 | $46,021,161 | 2 | Sony Pictures Releasing | - |
| 2 | 2 | - | Life as We Know It | $14,635,000 | $14,506,464 | -$128,536 | -0.9% | 3,150 | $14,635,000 | $14,506,464 | 1 | Warner Bros. | - |
| 3 | 3 | - | Secretariat | $12,600,000 | $12,694,770 | +$94,770 | +0.8% | 3,072 | $12,600,000 | $12,694,770 | 1 | Walt Disney Studios Motion Pictures | - |
| 4 | 4 | - | Legend of the Guardians: The Owls of Ga'Hoole | $7,015,000 | $6,888,019 | -$126,981 | -1.8% | 3,225 | $39,401,000 | $39,273,984 | 3 | Warner Bros. | - |
| 5 | 5 | - | My Soul to Take | $6,919,000 | $6,842,220 | -$76,780 | -1.1% | 2,572 | $6,919,000 | $6,842,220 | 1 | Universal Pictures | - |
| 6 | 6 | - | The Town | $6,350,000 | $6,411,008 | +$61,008 | +1% | 2,720 | $73,787,000 | $73,847,527 | 4 | Warner Bros. | - |
| 7 | 7 | - | Wall Street: Money Never Sleeps | $4,625,000 | $4,603,123 | -$21,877 | -0.5% | 2,829 | $43,667,000 | $43,644,701 | 3 | Twentieth Century Fox | - |
| 8 | 8 | - | Easy A | $4,200,000 | $4,289,418 | +$89,418 | +2.1% | 2,847 | $48,139,000 | $48,228,201 | 4 | Screen Gems | - |
| 9 | 9 | - | Case 39 | $2,630,000 | $2,680,305 | +$50,305 | +1.9% | 2,212 | $9,600,000 | $9,650,005 | 2 | Paramount Vantage | - |
| 10 | 10 | - | You Again | $2,474,000 | $2,512,782 | +$38,782 | +1.6% | 2,332 | $20,731,000 | $20,769,995 | 3 | Walt Disney Studios Motion Pictures | - |
| 11 | 11 | - | Let Me In | $2,400,000 | $2,447,618 | +$47,618 | +2% | 2,042 | $9,124,000 | $9,171,419 | 2 | Overture Films | - |
| 12 | 12 | - | It's Kind of a Funny Story | $2,012,000 | $2,013,406 | +$1,406 | <0.1% | 742 | $2,012,000 | $2,013,406 | 1 | Focus Features | - |
| 13 | 13 | - | Devil | $1,774,000 | $1,809,695 | +$35,695 | +2% | 1,442 | $30,010,000 | $30,046,530 | 4 | Universal Pictures | - |
| 14 | 14 | - | Alpha and Omega | $1,500,000 | $1,500,390 | +$390 | <0.1% | 1,616 | $21,018,000 | $21,018,064 | 4 | Lionsgate | - |
| 15 | 15 | - | Resident Evil: Afterlife | $1,250,000 | $1,255,120 | +$5,120 | +0.4% | 1,012 | $58,862,000 | $58,866,846 | 5 | Screen Gems | - |
| 16 | 16 | - | Waiting for Superman | $635,000 | $642,305 | +$7,305 | +1.2% | 103 | $1,410,000 | $1,417,256 | 3 | Paramount Vantage | - |
| 17 | 17 | - | Toy Story 3 | $539,000 | $555,096 | +$16,096 | +3% | 393 | $412,016,000 | $412,031,733 | 17 | Walt Disney Studios Motion Pictures | - |
| 18 | 18 | - | Inception | $510,000 | $492,311 | -$17,689 | -3.5% | 403 | $289,201,000 | $289,183,607 | 13 | Warner Bros. | - |
| 19 | 19 | - | Takers | $400,000 | $388,422 | -$11,578 | -2.9% | 412 | $56,785,000 | $56,773,203 | 7 | Screen Gems | - |
| 20 | 22 | +2 | Catfish | $374,000 | $292,359 | -$81,641 | -21.8% | 143 | $2,216,000 | $2,236,110 | 4 | Rogue Pictures | - |
| 21 | 21 | - | Never Let Me Go | $350,000 | $345,741 | -$4,259 | -1.2% | 167 | $1,154,000 | $1,149,704 | 4 | - | - |
| 22 | 20 | -2 | Despicable Me | $339,000 | $347,705 | +$8,705 | +2.6% | 353 | - | $246,557,455 | 14 | Universal Pictures | - |
| 23 | 23 | - | You Will Meet a Tall Dark Stranger | $282,000 | $270,175 | -$11,825 | -4.2% | 74 | $873,000 | $860,848 | 3 | Sony Pictures Classics | - |
| 24 | 25 | +1 | Buried | $200,000 | $221,694 | +$21,694 | +10.8% | 92 | $489,000 | $511,038 | 3 | Lionsgate | - |
| 25 | 27 | +2 | Mao's Last Dancer | $192,000 | $183,230 | -$8,770 | -4.6% | 121 | $3,746,000 | $3,737,348 | 8 | The Samuel Goldwyn Company | - |
| 26 | 29 | +3 | Nanny McPhee Returns | $145,000 | $149,415 | +$4,415 | +3% | 318 | $28,721,000 | $28,725,450 | 8 | Universal Pictures | - |
| 27 | 32 | +5 | The Expendables | $118,000 | $124,292 | +$6,292 | +5.3% | 225 | $102,729,000 | $102,734,893 | 9 | Lionsgate | - |
| 28 | 37 | +9 | Dinner for Schmucks | $100,000 | $100,482 | +$482 | +0.5% | 159 | $72,980,000 | $72,980,108 | 11 | DreamWorks | - |
| 29 | 39 | +10 | Get Low | $93,900 | $85,354 | -$8,546 | -9.1% | 143 | $8,809,000 | $8,800,251 | 11 | Sony Pictures Classics | - |
| 30 | 38 | +8 | The American | $81,700 | $85,672 | +$3,972 | +4.9% | 174 | $35,372,000 | $35,375,768 | 6 | Focus Features | - |
| 31 | 40 | +9 | Stone | $73,000 | $75,766 | +$2,766 | +3.8% | 6 | $73,000 | $75,766 | 1 | Overture Films | - |
| 32 | 45 | +13 | Nowhere Boy | $56,100 | $52,749 | -$3,351 | -6% | 4 | $56,100 | $52,749 | 1 | The Weinstein Company | - |
| 33 | 44 | +11 | Jack Goes Boating | $56,000 | $56,215 | +$215 | +0.4% | 90 | $372,000 | $372,305 | 4 | Overture Films | - |
| 34 | 49 | +15 | Howl | $51,200 | $48,306 | -$2,894 | -5.7% | 18 | $210,000 | $207,437 | 3 | Oscilloscope | - |
| 35 | 50 | +15 | Inside Job | $42,000 | $39,649 | -$2,351 | -5.6% | 2 | $42,000 | $39,649 | 1 | Sony Pictures Classics | - |
| 36 | 52 | +16 | The Twilight Saga: Eclipse | $39,000 | $38,013 | -$987 | -2.5% | 83 | $300,478,000 | $300,476,779 | 15 | Summit Entertainment | - |
| 37 | 55 | +18 | I Spit on Your Grave | $33,000 | $32,440 | -$560 | -1.7% | 12 | $33,000 | $32,440 | 1 | Anchor Bay Films | - |
| 38 | 56 | +18 | Piranha 3D | $25,400 | $29,302 | +$3,902 | +15.4% | 54 | $24,946,000 | $24,950,309 | 8 | - | - |
| 39 | 59 | +20 | Winter's Bone | $21,100 | $22,127 | +$1,027 | +4.9% | 52 | $6,166,000 | $6,167,021 | 18 | Roadside Attractions | - |
| 40 | 64 | +24 | Tamara Drewe | $19,300 | $18,604 | -$696 | -3.6% | 4 | $19,300 | $18,604 | 1 | Sony Pictures Classics | - |
| 41 | 65 | +24 | The Tillman Story | $17,500 | $17,508 | +$8 | <0.1% | 24 | $666,000 | $666,822 | 8 | The Weinstein Company | - |
| 42 | 77 | +35 | Animal Kingdom | $12,300 | $9,746 | -$2,554 | -20.8% | 26 | $921,000 | $918,090 | 9 | Sony Pictures Classics | - |
| 43 | 76 | +33 | Ghetto Physics | $10,200 | $10,087 | -$113 | -1.1% | 9 | $10,200 | $10,087 | 1 | The Samuel Goldwyn Company | - |
| 44 | 78 | +34 | The Concert | $8,800 | $8,306 | -$494 | -5.6% | 10 | $633,000 | $631,954 | 11 | The Weinstein Company | - |
| 45 | 79 | +34 | Budrus | $8,700 | $7,819 | -$881 | -10.1% | 1 | $8,700 | $7,819 | 1 | Balcony Releasing | - |
| 46 | 95 | +49 | Leaves of Grass | $4,100 | $3,801 | -$299 | -7.3% | 3 | $68,300 | $68,009 | 4 | First Look International | - |
| 47 | 113 | +66 | As Good as Dead | $2,100 | $1,494 | -$606 | -28.9% | 1 | $2,100 | $1,494 | 1 | First Look International | - |
| 48 | 110 | +62 | My Dog Tulip | $2,100 | $1,652 | -$448 | -21.3% | 1 | $70,900 | $70,434 | 6 | New Yorker Films | - |
