| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Skinning | $33,955 | -7.5% | 6 | - | $5,659 | $115,505 | 2 | N/A | false | false |
| 2 | - | The Other Guys | $12,397 | - | 7 | - | $1,771 | $12,397 | 1 | Sony Pictures Releasing | true | false |
| 3 | - | Legend of the Guardians: The Owls of Ga'Hoole | $7,935 | - | 7 | - | $1,133 | $8,764 | 1 | Warner Bros. | true | false |
| 4 | 5 | The Woman with a Broken Nose | $3,954 | +15% | 6 | - | $659 | $99,240 | 7 | N/A | false | false |
| 5 | 2 | Going the Distance | $3,710 | -42.1% | 6 | - | $618 | $30,023 | 3 | Warner Bros. | false | false |
| 6 | 4 | Grown Ups | $3,423 | -9.3% | 7 | - | $489 | $60,808 | 6 | Sony Pictures Releasing | false | false |
| 7 | 7 | Inception | $3,363 | +10.9% | 6 | - | $560 | $172,815 | 13 | Warner Bros. | false | false |
| 8 | 3 | Resident Evil: Afterlife | $2,505 | -41.8% | 6 | +1 | $417 | $53,686 | 4 | Sony Pictures Releasing | false | false |
| 9 | 6 | Despicable Me | $2,325 | -30.7% | 6 | - | $387 | $36,822 | 6 | United International Pictures | false | false |
| 10 | 8 | Step Up 3D | $2,275 | -11.1% | 3 | - | $758 | $9,667 | 3 | N/A | false | false |
| 11 | 9 | Machete | $1,376 | -33.8% | 3 | - | $458 | $25,845 | 5 | N/A | false | false |
| 12 | 10 | The Expendables | $1,093 | -37.4% | 5 | - | $218 | $123,540 | 8 | N/A | false | false |
| 13 | 13 | The Killer Inside Me | $898 | -3.4% | 1 | - | $898 | $8,865 | 5 | N/A | false | false |
| 14 | 15 | Letters to Juliet | $636 | +6.2% | 4 | - | $159 | $26,441 | 9 | N/A | false | false |
| 15 | 11 | The Karate Kid | $610 | -59.4% | 6 | -1 | $101 | $32,426 | 7 | Sony Pictures Releasing | false | false |
| 16 | 17 | The Last Airbender | $502 | +8% | 6 | - | $83 | $51,761 | 9 | United International Pictures | false | false |
| 17 | 14 | Cats & Dogs: The Revenge of Kitty Galore | $428 | -51.1% | 9 | - | $47 | $34,484 | 11 | Warner Bros. | false | false |
| 18 | 16 | Charlie St. Cloud | $103 | -78.5% | 5 | - | $20 | $11,992 | 5 | United International Pictures | false | false |
| 19 | 21 | When You're Strange | $78 | +8.3% | 1 | - | $78 | $11,241 | 12 | N/A | false | false |
| 20 | 18 | Predators | $49 | -78.2% | 7 | - | $7 | $31,736 | 10 | 20th Century Fox International | false | false |
| 21 | 20 | The Twilight Saga: Eclipse | $37 | -52.6% | 2 | -3 | $18 | $101,853 | 16 | N/A | false | false |
