| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Skinning | $36,719 | - | 6 | - | $6,119 | $54,609 | 1 | N/A | true | false |
| 2 | 2 | Going the Distance | $6,405 | -13.8% | 6 | - | $1,067 | $21,364 | 2 | Warner Bros. | false | false |
| 3 | 1 | Resident Evil: Afterlife | $4,306 | -69% | 5 | -3 | $861 | $49,927 | 3 | Sony Pictures Releasing | false | false |
| 4 | 3 | Grown Ups | $3,772 | -20.9% | 7 | - | $538 | $56,069 | 5 | Sony Pictures Releasing | false | false |
| 5 | 4 | The Woman with a Broken Nose | $3,439 | -20.3% | 6 | - | $573 | $92,411 | 6 | N/A | false | false |
| 6 | 6 | Despicable Me | $3,354 | +3.5% | 6 | - | $559 | $33,342 | 5 | United International Pictures | false | false |
| 7 | 5 | Inception | $3,033 | -20.5% | 6 | - | $505 | $166,674 | 12 | Warner Bros. | false | false |
| 8 | 9 | Step Up 3D | $2,559 | +2.8% | 3 | +1 | $853 | $6,412 | 2 | N/A | false | false |
| 9 | 7 | Machete | $2,077 | -31.6% | 3 | - | $692 | $23,209 | 4 | N/A | false | false |
| 10 | 8 | The Expendables | $1,745 | -31.1% | 5 | - | $349 | $121,287 | 7 | N/A | false | false |
| 11 | 11 | The Karate Kid | $1,503 | -7.5% | 7 | - | $214 | $31,504 | 6 | Sony Pictures Releasing | false | false |
| 12 | 10 | Killers | $1,099 | -35% | 3 | - | $366 | $83,750 | 14 | N/A | false | false |
| 13 | 13 | The Killer Inside Me | $930 | +28.1% | 1 | - | $930 | $7,432 | 4 | N/A | false | false |
| 14 | 14 | Cats & Dogs: The Revenge of Kitty Galore | $876 | +51% | 9 | - | $97 | $33,789 | 10 | Warner Bros. | false | false |
| 15 | 15 | Letters to Juliet | $599 | +16.8% | 4 | - | $149 | $25,348 | 8 | N/A | false | false |
| 16 | 12 | Charlie St. Cloud | $479 | -52.9% | 5 | - | $95 | $11,755 | 4 | United International Pictures | false | false |
| 17 | 17 | The Last Airbender | $465 | +12.3% | 6 | - | $77 | $51,096 | 8 | United International Pictures | false | false |
| 18 | 18 | Predators | $225 | -26% | 7 | - | $32 | $31,680 | 9 | 20th Century Fox International | false | false |
| 19 | 16 | Salt | $183 | -58.1% | 5 | - | $36 | $74,083 | 10 | Sony Pictures Releasing | false | false |
| 20 | 20 | The Twilight Saga: Eclipse | $78 | +8.3% | 5 | - | $15 | $101,730 | 15 | N/A | false | false |
| 21 | 19 | When You're Strange | $72 | -70.7% | 1 | - | $72 | $11,094 | 11 | N/A | false | false |
