| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Legend of the Guardians: The Owls of Ga'Hoole | $232,313 | -11.2% | 71 | -26 | $3,272 | $683,375 | 2 | Warner Bros. | false | false |
| 2 | - | Buried | $193,852 | - | 40 | - | $4,846 | $249,152 | 1 | N/A | true | false |
| 3 | - | Life as We Know It | $150,343 | - | 43 | - | $3,496 | $188,440 | 1 | Warner Bros. | true | false |
| 4 | 2 | Eat Pray Love | $127,165 | -19.3% | 55 | - | $2,312 | $952,696 | 4 | Sony Pictures Releasing | false | false |
| 5 | 4 | Gaturro | $124,191 | -10.5% | 59 | - | $2,104 | $1,682,847 | 5 | Distribution Company | false | false |
| 6 | 3 | No Return | $116,328 | -18% | 49 | -1 | $2,374 | $342,885 | 2 | Distribution Company | false | false |
| 7 | 7 | Avatar 2010 Special Edition | $95,893 | -6.8% | 50 | - | $1,917 | $372,344 | 3 | 20th Century Fox International | false | false |
| 8 | 5 | The Kids Are All Right | $88,136 | -17.1% | 29 | +3 | $3,039 | $238,643 | 2 | Alfa Films | false | false |
| 9 | 8 | The Last Exorcism | $80,120 | -16.2% | 41 | +1 | $1,954 | $963,764 | 5 | N/A | false | false |
| 10 | - | Charlie St. Cloud | $74,237 | - | 35 | - | $2,121 | $94,332 | 1 | Universal Pictures International (UPI) | true | false |
| 11 | 6 | Wall Street: Money Never Sleeps | $68,562 | -33.4% | 57 | +3 | $1,202 | $438,578 | 3 | 20th Century Fox International | false | false |
| 12 | 9 | I Love You Phillip Morris | $47,720 | -20.8% | 27 | +1 | $1,767 | $238,493 | 3 | N/A | false | false |
| 13 | 12 | Inception | $28,613 | -28.9% | 25 | -18 | $1,144 | $5,019,974 | 11 | Warner Bros. | false | false |
| 14 | 10 | Igualita a mí | $27,375 | -43.7% | 57 | -9 | $480 | $3,521,437 | 9 | Walt Disney Pictures | false | false |
| 15 | 13 | Tinker Bell and the Great Fairy Rescue | $25,833 | -23.2% | 41 | +4 | $630 | $588,204 | 6 | Walt Disney Pictures | false | false |
| 16 | - | Che: A New Man | $25,132 | - | 16 | - | $1,570 | $29,939 | 1 | Distribution Company | true | false |
| 17 | 14 | The Man Next Door | $24,416 | -19.2% | 24 | +1 | $1,017 | $455,077 | 6 | Primer Plano Film Group | false | false |
| 18 | 11 | The Expendables | $22,360 | -52.1% | 55 | -6 | $406 | $1,276,454 | 6 | Distribution Company | false | false |
| 19 | 15 | Killers | $14,647 | -37.9% | 25 | -3 | $585 | $244,538 | 5 | N/A | false | false |
| 20 | - | Everlasting Moments 2010 Re-release | $8,798 | - | 4 | - | $2,199 | $11,276 | 1 | Alfa Films | true | false |
| 21 | 17 | Cats & Dogs: The Revenge of Kitty Galore | $6,729 | -59.1% | 28 | -14 | $240 | $1,403,665 | 8 | Warner Bros. | false | false |
| 22 | 16 | The Descent: Part 2 | $6,542 | -63% | 39 | +13 | $167 | $76,743 | 3 | CDI Films | false | false |
| 23 | 19 | The Dancer and the Thief | $6,424 | -28.5% | 32 | +5 | $200 | $252,442 | 5 | Walt Disney Pictures | false | false |
| 24 | 24 | Going the Distance | $6,280 | -5.5% | 17 | -8 | $369 | $308,312 | 6 | Warner Bros. | false | false |
| 25 | 22 | The Last Airbender | $6,124 | -23.5% | 18 | -16 | $340 | $2,751,314 | 9 | Paramount Pictures International | false | false |
| 26 | 21 | Solitary Man | $6,060 | -25.3% | 15 | - | $404 | $222,025 | 7 | Distribution Company | false | false |
| 27 | 23 | Tell No One 2010 Re-release | $5,093 | -24.1% | 4 | - | $1,273 | $16,607 | 2 | N/A | false | false |
| 28 | 20 | Mademoiselle Chambon | $3,747 | -55.9% | 8 | -2 | $468 | $135,875 | 5 | CDI Films | false | false |
| 29 | 18 | Lula, the Son of Brazil | $2,688 | -82% | 7 | -12 | $384 | $61,211 | 3 | N/A | false | false |
| 30 | 27 | The Hedgehog | $2,282 | -10.5% | 7 | +1 | $326 | $83,534 | 6 | Impacto Cine | false | false |
| 31 | - | Whiskey with Vodka | $1,618 | - | 4 | - | $404 | $2,016 | 1 | Primer Plano Film Group | true | false |
| 32 | 41 | The Invisible Eye | $1,339 | +562.9% | 5 | +1 | $267 | $75,259 | 8 | Distribution Company | false | false |
| 33 | 29 | Despicable Me | $1,313 | -28.4% | 10 | -2 | $131 | $2,871,637 | 11 | Universal Pictures International (UPI) | false | false |
| 34 | 28 | Salt | $1,025 | -44.3% | 6 | +1 | $170 | $561,459 | 7 | Sony Pictures Releasing | false | false |
| 35 | 26 | Yuki and Nina | $887 | -79.4% | 4 | -2 | $221 | $22,497 | 3 | N/A | false | false |
| 36 | 36 | Predators | $865 | +41.1% | 8 | -7 | $108 | $552,721 | 9 | 20th Century Fox International | false | false |
| 37 | 34 | Neither God, Nor Master or Husband | $460 | -27.3% | 4 | -1 | $115 | $3,422 | 3 | Primer Plano Film Group | false | false |
| 38 | 31 | Still Walking | $444 | -67.4% | 1 | -1 | $444 | $44,390 | 6 | IFA | false | false |
| 39 | 42 | Shrek Forever After | $279 | +118% | 5 | -3 | $55 | $13,808,538 | 14 | Paramount Pictures International | false | false |
| 40 | 38 | The Sorcerer's Apprentice | $178 | -30.2% | 4 | -3 | $44 | $3,129,367 | 13 | Walt Disney Pictures | false | false |
| 41 | 37 | Vincere | $144 | -72.4% | 2 | - | $72 | $342,927 | 10 | CDI Films | false | false |
| 42 | 35 | Pájaros volando | $76 | -87.7% | 6 | +1 | $12 | $450,678 | 10 | Primer Plano Film Group | false | false |
| 43 | 25 | El rati horror show | $50 | -98.9% | 9 | -3 | $5 | $74,350 | 4 | Distribution Company | false | false |
| 44 | 43 | My Days with Gloria | $38 | -67.5% | 2 | +1 | $19 | $8,434 | 4 | N/A | false | false |
| 45 | 33 | Letters to Juliet | $28 | -96.1% | 2 | -2 | $14 | $398,187 | 18 | Alfa Films | false | false |
| 46 | 39 | Toy Story 3 | $23 | -90.6% | 3 | -4 | $7 | $16,026,307 | 17 | Walt Disney Pictures | false | false |
