| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Other Guys | $2,045,567 | -34% | 444 | +3 | $4,607 | $6,977,815 | 2 | Sony Pictures Releasing | false | false |
| 2 | - | Eat Pray Love | $1,844,659 | - | 433 | - | $4,260 | $1,844,659 | 1 | Sony Pictures Releasing | true | false |
| 3 | - | The Town | $1,591,057 | - | 321 | - | $4,956 | $1,591,057 | 1 | Warner Bros. | true | false |
| 4 | - | The Hole | $1,435,414 | - | 362 | - | $3,965 | $1,435,414 | 1 | N/A | true | false |
| 5 | 2 | Devil | $837,304 | -33.7% | 337 | -1 | $2,484 | $2,928,712 | 2 | Universal Pictures International (UPI) | false | false |
| 6 | 4 | Toy Story 3 | $747,925 | -18% | 398 | -57 | $1,879 | $114,632,765 | 10 | Walt Disney Pictures | false | false |
| 7 | 5 | Grown Ups | $608,091 | -24.3% | 327 | -60 | $1,859 | $10,931,423 | 5 | Sony Pictures Releasing | false | false |
| 8 | 3 | Resident Evil: Afterlife | $582,059 | -48.9% | 279 | -82 | $2,086 | $6,529,852 | 3 | Sony Pictures Releasing | false | false |
| 9 | 6 | Tamara Drewe | $388,873 | -42.5% | 290 | -67 | $1,340 | $3,330,735 | 3 | Momentum Pictures | false | false |
| 10 | 8 | Marmaduke | $386,723 | -11.5% | 392 | -12 | $986 | $7,617,992 | 6 | 20th Century Fox International | false | false |
| 11 | 9 | Diary of a Wimpy Kid | $324,913 | -13.9% | 341 | -9 | $952 | $3,621,144 | 5 | 20th Century Fox International | false | false |
| 12 | 12 | Inception | $275,750 | -12.3% | 124 | -8 | $2,223 | $55,826,373 | 11 | Warner Bros. | false | false |
| 13 | 7 | The Last Exorcism | $256,670 | -49% | 258 | -64 | $994 | $5,552,740 | 4 | Optimum Releasing | false | false |
| 14 | 10 | Scott Pilgrim vs. the World | $225,082 | -38.3% | 201 | -94 | $1,119 | $8,043,916 | 5 | Universal Pictures International (UPI) | false | false |
| 15 | - | Winter's Bone | $200,837 | - | 72 | - | $2,789 | $568,245 | 2 | Artificial Eye | false | false |
