| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Despicable Me | $2,658,409 | +25.1% | 402 | -3 | $6,612 | $16,915,400 | 5 | Universal Pictures International (UPI) | false | false |
| 2 | - | Legend of the Guardians: The Owls of Ga'Hoole | $1,326,666 | - | 347 | - | $3,823 | $1,699,808 | 1 | Roadshow Films | true | false |
| 3 | 3 | The Last Airbender | $1,190,678 | -18.7% | 319 | -22 | $3,732 | $7,723,216 | 3 | Paramount Pictures International | false | false |
| 4 | 2 | Wall Street: Money Never Sleeps | $1,132,195 | -31.5% | 283 | - | $4,000 | $3,668,640 | 2 | 20th Century Fox International | false | false |
| 5 | 8 | Diary of a Wimpy Kid | $1,071,263 | +49.8% | 213 | - | $5,029 | $3,380,885 | 2 | 20th Century Fox International | false | false |
| 6 | 6 | Cats & Dogs: The Revenge of Kitty Galore | $1,045,028 | +26% | 361 | -29 | $2,894 | $4,743,821 | 3 | Roadshow Films | false | false |
| 7 | - | Dinner for Schmucks | $1,035,450 | - | 212 | - | $4,884 | $1,035,450 | 1 | Paramount Pictures International | true | false |
| 8 | 4 | The Other Guys | $774,574 | -22.1% | 221 | -12 | $3,504 | $8,570,849 | 4 | Sony Pictures Releasing | false | false |
| 9 | 5 | Easy A | $712,124 | -18.8% | 163 | -4 | $4,368 | $4,055,090 | 3 | Sony Pictures Releasing | false | false |
| 10 | 7 | Tomorrow, When the War Began | $688,931 | -13.8% | 240 | -21 | $2,870 | $11,486,957 | 5 | Paramount Pictures International | false | false |
| 11 | 9 | Charlie St. Cloud | $465,737 | -23.1% | 164 | - | $2,839 | $1,572,423 | 2 | Universal Pictures International (UPI) | false | false |
| 12 | 11 | The Girl Who Played with Fire | $433,401 | -10.1% | 87 | +4 | $4,981 | $1,265,732 | 2 | Rialto Distribution | false | false |
| 13 | 10 | The Sorcerer's Apprentice | $426,023 | -17.9% | 215 | -16 | $1,981 | $4,248,985 | 4 | Walt Disney Pictures | false | false |
| 14 | 12 | Inception | $178,234 | -2.1% | 57 | -20 | $3,126 | $34,247,394 | 11 | Warner Bros. | false | false |
| 15 | - | Anjaana Anjaani | $103,297 | - | 13 | - | $7,945 | $103,297 | 1 | Eros Worldwide | true | false |
| 16 | 13 | Salt | $83,959 | -42.4% | 64 | -23 | $1,311 | $12,070,066 | 7 | Sony Pictures Releasing | false | false |
| 17 | 15 | Boy | $81,556 | -0.6% | 31 | - | $2,630 | $1,488,050 | 6 | Paramount Pictures International | false | false |
| 18 | 14 | The Kids Are All Right | $79,925 | -14.7% | 43 | -6 | $1,858 | $1,427,565 | 5 | Hopscotch Films | false | false |
| 19 | - | The Tree | $67,973 | - | 21 | - | $3,236 | $111,345 | 1 | Paramount Pictures International | true | false |
| 20 | 16 | Hubble | $52,126 | +25.3% | 4 | -2 | $13,031 | $670,531 | 8 | IMAX | false | false |
