| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Resident Evil: Afterlife | $334,317 | -55.1% | 98 | - | $3,411 | $1,326,730 | 2 | Sony Pictures Releasing | false | false |
| 2 | - | The Edge | $73,566 | - | 45 | - | $1,634 | $73,566 | 1 | N/A | true | false |
| 3 | 2 | Alpha and Omega | $46,082 | -34.9% | 45 | - | $1,024 | $128,294 | 2 | N/A | false | false |
| 4 | - | Sea Rex 3D: Journey to a Prehistoric World | $41,759 | - | 32 | - | $1,304 | $41,759 | 1 | N/A | true | false |
| 5 | 3 | Going the Distance | $36,110 | -46.8% | 44 | - | $820 | $255,573 | 3 | Warner Bros. | false | false |
| 6 | 4 | The American | $22,604 | -42.8% | 20 | - | $1,130 | $178,921 | 3 | N/A | false | false |
| 7 | - | A Yakuza's Daughter Never Cries | $18,120 | - | 17 | - | $1,065 | $18,120 | 1 | N/A | true | false |
| 8 | 6 | Inception | $12,798 | -26.6% | 13 | -1 | $984 | $1,450,447 | 10 | Warner Bros. | false | false |
| 9 | 9 | The Joneses | $10,036 | -19.7% | 11 | - | $912 | $68,394 | 4 | N/A | false | false |
| 10 | 8 | Moskva, ya lyublyu tebya! | $9,740 | -40.6% | 36 | +8 | $270 | $172,775 | 4 | N/A | false | false |
| 11 | 14 | Avatar | $3,999 | +226.7% | 3 | +2 | $1,333 | $8,466,555 | 41 | 20th Century Fox International | false | false |
| 12 | 11 | The Karate Kid | $1,500 | -72.4% | 22 | -13 | $68 | $315,661 | 6 | Sony Pictures Releasing | false | false |
| 13 | 17 | Tinker Bell and the Great Fairy Rescue | $1,390 | +117.2% | 8 | -1 | $173 | $82,678 | 7 | Walt Disney Pictures | false | false |
| 14 | 12 | Cats & Dogs: The Revenge of Kitty Galore | $1,136 | -73.1% | 3 | -6 | $378 | $516,886 | 9 | Warner Bros. | false | false |
| 15 | 13 | Grown Ups | $910 | -46.8% | 9 | -9 | $101 | $700,188 | 8 | Sony Pictures Releasing | false | false |
| 16 | 15 | Shrek Forever After | $888 | -21.7% | 1 | - | $888 | $4,032,447 | 19 | Paramount Pictures International | false | false |
| 17 | 21 | Step Up 3D | $775 | +449.6% | 2 | +1 | $387 | $483,402 | 7 | N/A | false | false |
| 18 | 16 | Despicable Me | $693 | -36.2% | 2 | -2 | $346 | $1,100,958 | 11 | Universal Pictures International (UPI) | false | false |
| 19 | 20 | Toy Story 3 | $639 | +328.9% | 4 | +2 | $159 | $667,965 | 14 | Walt Disney Pictures | false | false |
| 20 | - | The Alien Girl | $561 | - | 1 | - | $561 | $118,941 | 13 | N/A | false | false |
| 21 | 19 | The Sorcerer's Apprentice | $397 | -10% | 1 | -2 | $397 | $1,231,202 | 10 | Walt Disney Pictures | false | false |
| 22 | 18 | Salt | $292 | -46.5% | 2 | -1 | $146 | $1,242,659 | 9 | Sony Pictures Releasing | false | false |
| 23 | 23 | The Twilight Saga: Eclipse | $122 | +15.1% | 2 | +1 | $61 | $1,686,847 | 12 | N/A | false | false |
| 24 | 22 | Predators | $36 | -68.4% | 2 | -1 | $18 | $397,497 | 12 | 20th Century Fox International | false | false |
