| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Grown Ups | $90,217 | -37.6% | 15 | - | $6,014 | $268,110 | 2 | Sony Pictures Releasing | false | false |
| 2 | 1 | Cats & Dogs: The Revenge of Kitty Galore | $63,175 | -57.2% | 30 | -16 | $2,105 | $489,395 | 3 | Warner Bros. | false | false |
| 3 | 3 | The Last Airbender | $32,916 | -50.3% | 27 | -16 | $1,219 | $2,943,871 | 5 | United International Pictures | false | false |
| 4 | 4 | Salt | $19,494 | -40.5% | 15 | -22 | $1,299 | $2,586,713 | 6 | Sony Pictures Releasing | false | false |
| 5 | 5 | The Book of Eli | $15,769 | +49.5% | 11 | +7 | $1,433 | $597,433 | 21 | Sony Pictures Releasing | false | false |
| 6 | 10 | The Karate Kid | $7,296 | +205% | 4 | - | $1,824 | $3,346,220 | 13 | Sony Pictures Releasing | false | false |
| 7 | 8 | The Sorcerer's Apprentice | $6,485 | +114.6% | 2 | -2 | $3,242 | $1,913,041 | 7 | Walt Disney Pictures | false | false |
| 8 | 6 | Inception | $2,794 | -45.6% | 2 | -3 | $1,397 | $2,369,800 | 8 | Warner Bros. | false | false |
| 9 | 7 | Prince of Persia: The Sands of Time | $615 | -81.3% | 1 | -1 | $615 | $4,103,526 | 15 | Walt Disney Pictures | false | false |
| 10 | 9 | Despicable Me | $241 | -90.6% | 1 | -3 | $241 | $1,494,925 | 9 | United International Pictures | false | false |
