| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Expendables | $30,492 | - | 5 | - | $6,098 | $39,701 | 1 | N/A | true | false |
| 2 | 1 | The Last Airbender | $6,777 | -28.4% | 6 | - | $1,129 | $29,998 | 2 | United International Pictures | false | false |
| 3 | 3 | Inception | $4,945 | +4% | 6 | - | $824 | $117,672 | 6 | Warner Bros. | false | false |
| 4 | 2 | Salt | $3,977 | -27.5% | 7 | - | $568 | $61,166 | 4 | Sony Pictures Releasing | false | false |
| 5 | 5 | Letters to Juliet | $2,656 | -11.1% | 4 | - | $664 | $9,914 | 2 | N/A | false | false |
| 6 | 6 | Shrek Forever After | $2,253 | -9.3% | 7 | - | $321 | $160,912 | 14 | United International Pictures | false | false |
| 7 | 4 | Predators | $1,835 | -47.7% | 7 | - | $262 | $23,991 | 3 | 20th Century Fox International | false | false |
| 8 | 9 | Cats & Dogs: The Revenge of Kitty Galore | $1,833 | +17.5% | 9 | - | $203 | $23,810 | 4 | Warner Bros. | false | false |
| 9 | 10 | Killers | $1,356 | +23.2% | 3 | - | $452 | $66,542 | 8 | N/A | false | false |
| 10 | 7 | Sex and the City 2 | $1,177 | -47.5% | 9 | - | $130 | $369,325 | 13 | Warner Bros. | false | false |
| 11 | 14 | Toy Story 3 | $964 | +32.4% | 7 | - | $137 | $68,165 | 11 | Walt Disney Pictures | false | false |
| 12 | 11 | Prince of Persia: The Sands of Time | $821 | -15.9% | 6 | - | $136 | $154,010 | 13 | Walt Disney Pictures | false | false |
| 13 | 8 | The Twilight Saga: Eclipse | $753 | -51.8% | 5 | - | $150 | $92,559 | 9 | N/A | false | false |
| 14 | 12 | The Sorcerer's Apprentice | $726 | -22% | 4 | - | $181 | $50,704 | 7 | United International Pictures | false | false |
| 15 | 16 | The Back-up Plan | $638 | +107.1% | 4 | +3 | $159 | $58,882 | 11 | Sony Pictures Releasing | false | false |
| 16 | 15 | A Nightmare on Elm Street | $597 | -8.6% | 6 | - | $99 | $59,169 | 11 | Warner Bros. | false | false |
| 17 | 13 | Knight and Day 2010 Re-release | $577 | -34.1% | 7 | - | $82 | $34,398 | 5 | 20th Century Fox International | false | false |
| 18 | 17 | When You're Strange | $245 | -8.9% | 1 | - | $245 | $8,535 | 5 | N/A | false | false |
| 19 | 19 | Robin Hood | $153 | +15% | 7 | - | $21 | $161,619 | 16 | United International Pictures | false | false |
| 20 | 20 | Get Him to the Greek | $42 | -52.8% | 4 | - | $10 | $14,540 | 6 | United International Pictures | false | false |
| 21 | - | Paintball | $2 | - | 1 | - | $2 | $5,598 | 10 | N/A | false | false |
