| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Toy Story 3 | $4,932,928 | -33.7% | 569 | +14 | $8,669 | $91,873,545 | 4 | Walt Disney Pictures | false | false |
| 2 | 3 | Inception | $2,621,891 | -27.2% | 472 | +4 | $5,554 | $45,546,749 | 5 | Warner Bros. | false | false |
| 3 | - | The Last Airbender | $2,579,229 | - | 450 | - | $5,731 | $2,579,229 | 1 | Paramount Pictures International | true | false |
| 4 | 2 | Knight and Day 2010 Re-release | $2,385,374 | -37.8% | 441 | +7 | $5,409 | $9,214,905 | 2 | 20th Century Fox International | false | false |
| 5 | - | The Sorcerer's Apprentice | $1,778,774 | - | 406 | - | $4,381 | $1,778,774 | 1 | Walt Disney Pictures | true | false |
| 6 | 4 | Step Up 3D | $1,681,405 | -47.7% | 401 | +1 | $4,193 | $7,714,855 | 2 | Universal Pictures International (UPI) | false | false |
| 7 | 6 | The Karate Kid | $1,192,701 | -47% | 428 | -18 | $2,786 | $16,532,359 | 3 | Sony Pictures Releasing | false | false |
| 8 | 7 | The A-Team | $1,189,304 | -46.2% | 413 | -40 | $2,879 | $13,904,749 | 3 | 20th Century Fox International | false | false |
| 9 | 5 | Cats & Dogs: The Revenge of Kitty Galore | $762,496 | -69.2% | 480 | +72 | $1,588 | $5,019,561 | 2 | Warner Bros. | false | false |
| 10 | - | Tinker Bell and the Great Fairy Rescue | $450,013 | - | 236 | - | $1,906 | $450,013 | 1 | Walt Disney Pictures | true | false |
| 11 | 8 | Shrek Forever After | $384,964 | -33.4% | 306 | -101 | $1,258 | $48,513,057 | 7 | Paramount Pictures International | false | false |
| 12 | 9 | The Twilight Saga: Eclipse | $231,677 | -55.2% | 174 | -97 | $1,331 | $45,709,785 | 6 | Entertainment One | false | false |
| 13 | - | The Secret in Their Eyes | $133,294 | - | 16 | - | $8,330 | $133,294 | 1 | - | true | false |
| 14 | 11 | Coco Chanel & Igor Stravinsky | $67,727 | -19.7% | 44 | +8 | $1,539 | $230,602 | 2 | Soda Pictures | false | false |
| 15 | 10 | Gainsbourg: A Heroic Life | $64,143 | -53.8% | 34 | -16 | $1,886 | $725,732 | 3 | Optimum Releasing | false | false |
