| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Inception | $668,941 | -25.1% | 103 | - | $6,494 | $5,607,570 | 4 | Warner Bros. | false | false |
| 2 | 2 | Step Up 3D | $622,132 | -27.5% | 89 | - | $6,990 | $1,940,264 | 2 | Independent Films | false | false |
| 3 | 3 | Salt | $487,711 | -32.7% | 80 | +1 | $6,096 | $1,496,120 | 2 | Sony Pictures Releasing | false | false |
| 4 | 4 | Shrek Forever After | $337,774 | -22.3% | 200 | -10 | $1,688 | $5,918,339 | 6 | Universal Pictures International (UPI) | false | false |
| 5 | - | Marmaduke | $313,149 | - | 77 | - | $4,066 | $419,219 | 1 | Warner Bros. | true | false |
| 6 | 8 | Toy Story 3 | $243,679 | -16.2% | 130 | -12 | $1,874 | $4,754,032 | 8 | Walt Disney Pictures | false | false |
| 7 | 5 | The Karate Kid | $217,565 | -32.7% | 85 | - | $2,559 | $3,220,476 | 4 | Sony Pictures Releasing | false | false |
| 8 | 6 | A Turtle's Tale: Sammy's Adventures | $217,311 | -29.6% | 93 | - | $2,336 | $842,359 | 2 | Universal Pictures International (UPI) | false | false |
| 9 | 7 | The Sorcerer's Apprentice | $201,171 | -34.6% | 95 | - | $2,117 | $1,435,912 | 3 | Walt Disney Pictures | false | false |
| 10 | 9 | Knight and Day 2010 Re-release | $159,851 | -23.4% | 100 | -5 | $1,598 | $2,781,136 | 5 | Warner Bros. | false | false |
| 11 | 10 | Cats & Dogs: The Revenge of Kitty Galore | $112,689 | -33.2% | 94 | +1 | $1,198 | $884,050 | 3 | Warner Bros. | false | false |
| 12 | - | The Joneses | $70,254 | - | 18 | - | $3,903 | $86,065 | 1 | Benelux Film Distributors | true | false |
| 13 | 11 | Predators | $61,731 | -42.8% | 43 | -4 | $1,435 | $581,090 | 3 | Warner Bros. | false | false |
| 14 | 12 | The Twilight Saga: Eclipse | $48,142 | -33% | 45 | -13 | $1,069 | $3,610,020 | 7 | Independent Films | false | false |
| 15 | 13 | Certified Copy | $33,902 | -16.6% | 9 | - | $3,766 | $96,012 | 2 | Wild Bunch Distribution | false | false |
| 16 | 15 | Brooklyn's Finest 2010 Re-release | $20,093 | -37.6% | 15 | -4 | $1,339 | $178,698 | 3 | Benelux Film Distributors | false | false |
| 17 | 14 | Furry Vengeance | $18,734 | -42.7% | 44 | -9 | $425 | $307,394 | 5 | Entertainment One | false | false |
| 18 | - | Hideaway | $15,570 | - | 12 | - | $1,297 | $20,864 | 1 | N/A | true | false |
| 19 | 16 | My Afternoons with Margueritte | $15,021 | -16.3% | 10 | +2 | $1,502 | $77,738 | 3 | Cinéart | false | false |
| 20 | - | The Ghost Writer | $14,572 | - | 15 | - | $971 | $624,652 | 13 | Benelux Film Distributors | false | false |
