| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Marmaduke | $940,960 | - | - | - | - | $941,291 | 1 | 20th Century Fox International | true | false |
| 2 | 1 | Toy Story 3 | $574,491 | +14.7% | - | - | - | $16,380,791 | 6 | Walt Disney Pictures | false | false |
| 3 | - | Splice 2010 Re-release | $279,855 | - | - | - | - | $317,565 | 1 | N/A | true | false |
| 4 | 2 | Pandorum | $244,847 | -17.3% | - | - | - | $734,525 | 2 | Eagle Pictures | false | false |
| 5 | 3 | The Box | $193,613 | -27% | - | - | - | $1,672,575 | 4 | Lucky Red | false | false |
| 6 | 5 | Solomon Kane | $154,114 | +15.6% | - | - | - | $2,395,018 | 5 | Eagle Pictures | false | false |
| 7 | 4 | The Twilight Saga: Eclipse | $131,762 | -13.6% | - | - | - | $19,879,059 | 7 | Eagle Pictures | false | false |
| 8 | 7 | The Losers | $66,025 | -11% | - | - | - | $644,530 | 4 | Warner Bros. | false | false |
| 9 | 6 | Predators | $58,184 | -29.1% | - | - | - | $2,012,157 | 5 | 20th Century Fox International | false | false |
| 10 | 9 | Basilicata Coast to Coast | $56,896 | +37.7% | - | - | - | $4,086,084 | 19 | Eagle Pictures | false | false |
| 11 | 8 | The Soloist | $50,392 | +3.6% | - | - | - | $446,847 | 4 | United International Pictures | false | false |
| 12 | - | Alone 2010 Re-release | $24,016 | - | - | - | - | $24,016 | 1 | Wave Distribution | true | false |
| 13 | - | The Secret in Their Eyes | $18,929 | - | - | - | - | $1,249,745 | 11 | Lucky Red | false | false |
| 14 | - | The A-Team | $17,537 | - | - | - | - | $3,030,414 | 9 | 20th Century Fox International | false | false |
| 15 | - | Avatar | $17,507 | - | - | - | - | $83,760,660 | 31 | 20th Century Fox International | false | false |
| 16 | 10 | Coming Soon | $15,715 | -34.4% | - | - | - | $57,904 | 2 | Wave Distribution | false | false |
| 17 | - | Loose Cannons | $11,514 | - | - | - | - | $10,633,055 | 23 | 01 Distribution | false | false |
| 18 | - | Just Wright | $10,142 | - | - | - | - | $10,142 | 1 | N/A | true | false |
| 19 | - | The Marc Pease Experience | $9,744 | - | - | - | - | $368,331 | 5 | N/A | false | false |
| 20 | - | The Book of Masters | $9,305 | - | - | - | - | $33,959 | 4 | Walt Disney Pictures | false | false |
