| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Inception | $893,176 | -21.4% | 103 | - | $8,671 | $4,743,468 | 3 | Warner Bros. | false | false |
| 2 | - | Step Up 3D | $857,664 | - | 89 | - | $9,636 | $873,567 | 1 | Independent Films | true | false |
| 3 | - | Salt | $724,511 | - | 79 | - | $9,171 | $724,511 | 1 | Sony Pictures Releasing | true | false |
| 4 | 2 | Shrek Forever After | $434,700 | -27.6% | 210 | -15 | $2,070 | $5,538,941 | 5 | Universal Pictures International (UPI) | false | false |
| 5 | 3 | The Karate Kid | $323,128 | -34.9% | 85 | +1 | $3,801 | $2,945,361 | 3 | Sony Pictures Releasing | false | false |
| 6 | - | A Turtle's Tale: Sammy's Adventures | $308,861 | - | 93 | - | $3,321 | $451,828 | 1 | Universal Pictures International (UPI) | true | false |
| 7 | 4 | The Sorcerer's Apprentice | $307,519 | -37.6% | 95 | - | $3,237 | $1,141,227 | 2 | Walt Disney Pictures | false | false |
| 8 | 5 | Toy Story 3 | $290,767 | -25.6% | 142 | -17 | $2,047 | $4,510,136 | 7 | Walt Disney Pictures | false | false |
| 9 | 6 | Knight and Day 2010 Re-release | $208,713 | -43.9% | 105 | -3 | $1,987 | $2,620,382 | 4 | Warner Bros. | false | false |
| 10 | 8 | Cats & Dogs: The Revenge of Kitty Galore | $168,698 | -23.2% | 93 | - | $1,813 | $678,702 | 2 | Warner Bros. | false | false |
| 11 | 7 | Predators | $107,910 | -54.9% | 47 | - | $2,295 | $485,205 | 2 | Warner Bros. | false | false |
| 12 | 9 | The Twilight Saga: Eclipse | $71,844 | -40.5% | 58 | -34 | $1,238 | $3,662,517 | 6 | Independent Films | false | false |
| 13 | - | Certified Copy | $40,638 | - | 9 | - | $4,515 | $43,457 | 1 | Wild Bunch Distribution | true | false |
| 14 | 11 | Furry Vengeance | $32,674 | +3.7% | 53 | -11 | $616 | $277,242 | 4 | Entertainment One | false | false |
| 15 | 10 | Brooklyn's Finest 2010 Re-release | $32,217 | -46.3% | 19 | - | $1,695 | $150,890 | 2 | Benelux Film Distributors | false | false |
| 16 | 15 | My Afternoons with Margueritte | $17,941 | -6.1% | 8 | - | $2,242 | $55,048 | 2 | Cinéart | false | false |
| 17 | 12 | Sex and the City 2 | $17,501 | -27.2% | 11 | -8 | $1,591 | $5,230,898 | 11 | Warner Bros. | false | false |
| 18 | 20 | Me Too | $17,409 | +14.4% | 13 | - | $1,339 | $382,213 | 13 | A-Film Distribution | false | false |
| 19 | 14 | Letters to Juliet | $16,859 | -26.9% | 21 | +1 | $802 | $734,821 | 8 | Entertainment One | false | false |
| 20 | 19 | Greenberg | $14,794 | -4.1% | 7 | +1 | $2,113 | $122,489 | 5 | Benelux Film Distributors | false | false |
