| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Despicable Me | $596,557 | -13.8% | 145 | +5 | $4,114 | $1,543,500 | 2 | Universal Pictures International (UPI) | false | false |
| 2 | - | Inception | $514,049 | - | 138 | - | $3,724 | $514,049 | 1 | Warner Bros. | true | false |
| 3 | 3 | The Sorcerer's Apprentice | $263,568 | -28.6% | 98 | -4 | $2,689 | $2,429,119 | 4 | Walt Disney Pictures | false | false |
| 4 | 2 | Shrek Forever After | $241,148 | -43% | 112 | -7 | $2,153 | $6,378,380 | 5 | United International Pictures | false | false |
| 5 | - | Grown Ups | $170,825 | - | 50 | - | $3,416 | $170,825 | 1 | Sony Pictures Releasing | true | false |
| 6 | 4 | Salt | $106,809 | -39.9% | 65 | - | $1,643 | $706,835 | 3 | Sony Pictures Releasing | false | false |
| 7 | 7 | Toy Story 3 | $52,138 | +25% | 53 | -12 | $983 | $10,480,585 | 8 | Walt Disney Pictures | false | false |
| 8 | 6 | The Twilight Saga: Eclipse | $21,642 | -70.5% | 26 | -45 | $832 | $3,033,231 | 6 | Cine Colombia | false | false |
| 9 | 5 | Knight and Day 2010 Re-release | $19,625 | -74.2% | 22 | -43 | $892 | $714,396 | 4 | 20th Century Fox International | false | false |
| 10 | 8 | Eden Lake | $9,485 | -65.6% | 14 | -8 | $677 | $95,758 | 3 | Cine Colombia | false | false |
| 11 | 11 | Cherry Blossoms | $6,225 | -25.5% | 5 | - | $1,245 | $82,361 | 5 | Cine Colombia | false | false |
| 12 | 10 | The Karate Kid | $3,215 | -78.7% | 5 | -20 | $643 | $1,558,647 | 8 | Sony Pictures Releasing | false | false |
| 13 | 9 | My Life in Ruins | $2,814 | -89.1% | 7 | -13 | $402 | $41,259 | 2 | Cine Colombia | false | false |
| 14 | 13 | A Nightmare on Elm Street | $1,381 | -33.9% | 1 | - | $1,381 | $1,406,599 | 13 | Warner Bros. | false | false |
| 15 | 14 | Two Lovers | $866 | -7.5% | 1 | - | $866 | $47,083 | 9 | Cine Colombia | false | false |
| 16 | 12 | The Back-up Plan | $502 | -85.1% | 1 | -2 | $502 | $378,155 | 8 | Sony Pictures Releasing | false | false |
