| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Shrek Forever After | $1,181,813 | -29.2% | 179 | +33 | $6,602 | $3,535,150 | 2 | United International Pictures | false | false |
| 2 | - | The Sorcerer's Apprentice | $555,674 | - | 116 | - | $4,790 | $558,303 | 1 | Walt Disney Pictures | true | false |
| 3 | 2 | Toy Story 3 | $289,971 | -40.5% | 121 | -25 | $2,396 | $9,571,633 | 5 | Walt Disney Pictures | false | false |
| 4 | 3 | The Twilight Saga: Eclipse | $211,914 | -54.7% | 110 | -47 | $1,926 | $2,478,242 | 3 | Cine Colombia | false | false |
| 5 | - | Knight and Day 2010 Re-release | $192,233 | - | 98 | - | $1,961 | $224,703 | 1 | 20th Century Fox International | true | false |
| 6 | 4 | The Karate Kid | $45,773 | -72.4% | 53 | -27 | $863 | $1,456,782 | 5 | Sony Pictures Releasing | false | false |
| 7 | 6 | Cherry Blossoms | $11,976 | -9.7% | 5 | -2 | $2,395 | $34,895 | 2 | Cine Colombia | false | false |
| 8 | 5 | Prince of Persia: The Sands of Time | $4,258 | -77.1% | 8 | -17 | $532 | $3,868,735 | 8 | Walt Disney Pictures | false | false |
| 9 | 8 | The Spy Next Door 2010 Re-release | $3,109 | -71.5% | 9 | -1 | $345 | $70,271 | 3 | Cineplex | false | false |
| 10 | 7 | The A-Team | $2,286 | -79.3% | 5 | -12 | $457 | $825,969 | 6 | 20th Century Fox International | false | false |
| 11 | 11 | Two Lovers | $1,609 | -18.4% | 2 | - | $804 | $40,581 | 6 | Cine Colombia | false | false |
| 12 | 12 | A Nightmare on Elm Street | $895 | -43.9% | 2 | -3 | $447 | $1,348,820 | 10 | Warner Bros. | false | false |
| 13 | 9 | The Back-up Plan | $651 | -90.3% | 1 | -12 | $651 | $370,920 | 5 | Sony Pictures Releasing | false | false |
| 14 | 15 | Nanny McPhee Returns | $629 | -35.3% | 3 | -2 | $209 | $170,857 | 6 | United International Pictures | false | false |
