| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Schuks Tshabalala's Survival Guide to South Africa | $463,411 | -1.2% | 110 | - | $4,212 | $1,208,354 | 2 | N/A | false | false |
| 2 | 3 | Prince of Persia: The Sands of Time | $170,279 | -19% | 93 | - | $1,830 | $898,319 | 3 | Walt Disney Pictures | false | false |
| 3 | 2 | Sex and the City 2 | $156,015 | -42.9% | 72 | +1 | $2,166 | $553,183 | 2 | 20th Century Fox International | false | false |
| 4 | - | Killers | $146,945 | - | 50 | - | $2,938 | $146,945 | 1 | NuMetro Distribution | true | false |
| 5 | 4 | Robin Hood | $80,999 | -20.8% | 80 | +7 | $1,012 | $748,369 | 4 | United International Pictures | false | false |
| 6 | 5 | Iron Man 2 | $68,227 | -32.1% | 78 | - | $874 | $2,074,447 | 6 | Paramount Pictures International | false | false |
| 7 | 6 | Green Zone 2010 Re-release | $56,961 | -17.6% | 45 | - | $1,265 | $165,270 | 2 | United International Pictures | false | false |
| 8 | 7 | Space Chimps 2: Zartog Strikes Back | $55,761 | -1.1% | 27 | - | $2,065 | $120,552 | 2 | United International Pictures | false | false |
| 9 | 8 | The Back-up Plan | $38,287 | -20.1% | 31 | -7 | $1,235 | $586,334 | 5 | Sony Pictures Releasing | false | false |
| 10 | - | Legion | $31,644 | - | 25 | - | $1,265 | $31,644 | 1 | Sony Pictures Releasing | true | false |
| 11 | 9 | The Last Song | $23,928 | -33.4% | 21 | -6 | $1,139 | $244,491 | 4 | Walt Disney Pictures | false | false |
| 12 | 13 | A Serious Man | $8,450 | -30.2% | 8 | - | $1,056 | $56,406 | 4 | Ster-Kinekor Pictures | false | false |
| 13 | 10 | Kites | $7,298 | -60.9% | 7 | -5 | $1,042 | $74,464 | 3 | N/A | false | false |
| 14 | 17 | Edge of Darkness | $5,909 | -21.3% | 10 | -6 | $590 | $244,920 | 5 | NuMetro Distribution | false | false |
| 15 | 12 | I Now Pronounce You Black and White | $5,762 | -53.5% | 11 | -10 | $523 | $126,218 | 4 | N/A | false | false |
| 16 | 16 | The Last Station 2010 Re-release | $4,059 | -48.9% | 6 | - | $676 | $145,046 | 11 | Ster-Kinekor Pictures | false | false |
| 17 | - | To Save a Life | $3,765 | - | 20 | - | $188 | $3,765 | 1 | NuMetro Distribution | true | false |
| 18 | 22 | Seraphine | $2,963 | +6.2% | 3 | - | $987 | $24,270 | 5 | Ster-Kinekor Pictures | false | false |
| 19 | 20 | The Men Who Stare at Goats | $2,901 | -7.7% | 4 | -3 | $725 | $71,929 | 6 | NuMetro Distribution | false | false |
| 20 | 11 | The Ghost Writer | $2,806 | -78.2% | 4 | -16 | $701 | $56,239 | 3 | NuMetro Distribution | false | false |
| 21 | 23 | Paris 36 | $2,783 | +6.2% | 3 | - | $927 | $6,858 | 2 | Ster-Kinekor Pictures | false | false |
| 22 | 18 | How to Train Your Dragon | $2,251 | -46.2% | 16 | - | $140 | $2,080,198 | 11 | United International Pictures | false | false |
| 23 | 24 | Nanny McPhee Returns | $1,290 | -11.8% | 6 | - | $215 | $544,537 | 10 | United International Pictures | false | false |
| 24 | 26 | Leap Year | $453 | +26.9% | 4 | - | $113 | $281,741 | 8 | United International Pictures | false | false |
