| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Iron Man 2 | $679,085 | - | 79 | - | $8,596 | $679,085 | 1 | Paramount Pictures International | true | false |
| 2 | 1 | Clash of the Titans | $144,795 | -48% | 85 | +2 | $1,703 | $1,257,615 | 3 | Warner Bros. | false | false |
| 3 | - | Love Happens | $66,651 | - | 35 | - | $1,904 | $66,651 | 1 | Ster-Kinekor Pictures | true | false |
| 4 | 3 | Date Night | $66,446 | -33.8% | 53 | -6 | $1,253 | $689,047 | 4 | 20th Century Fox International | false | false |
| 5 | 5 | When in Rome | $62,818 | -31.4% | 30 | - | $2,093 | $237,877 | 2 | Walt Disney Pictures | false | false |
| 6 | 4 | The Bounty Hunter | $60,728 | -38.2% | 49 | -7 | $1,239 | $1,373,761 | 5 | Sony Pictures Releasing | false | false |
| 7 | 2 | How to Train Your Dragon | $57,144 | -43.7% | 59 | -9 | $968 | $2,088,875 | 6 | United International Pictures | false | false |
| 8 | 6 | Jakhalsdans | $55,550 | -30.3% | 39 | -1 | $1,424 | $220,643 | 2 | N/A | false | false |
| 9 | 7 | Leap Year | $28,210 | -46.6% | 35 | -9 | $806 | $245,616 | 3 | United International Pictures | false | false |
| 10 | 8 | Kick-Ass | $27,482 | -45.7% | 41 | +1 | $670 | $125,801 | 2 | NuMetro Distribution | false | false |
| 11 | 9 | Tooth Fairy | $25,339 | -39.8% | 40 | -7 | $633 | $1,517,291 | 7 | 20th Century Fox International | false | false |
| 12 | 11 | Nanny McPhee Returns | $25,267 | -36.5% | 30 | -5 | $842 | $518,784 | 5 | United International Pictures | false | false |
| 13 | 13 | The Accidental Husband | $24,550 | -27.7% | 20 | - | $1,227 | $92,746 | 2 | Ster-Kinekor Pictures | false | false |
| 14 | 10 | Hachi: A Dog's Tale | $19,892 | -51.4% | 23 | -1 | $864 | $168,418 | 3 | Ster-Kinekor Pictures | false | false |
| 15 | - | The Men Who Stare at Goats | $19,682 | - | 15 | - | $1,312 | $19,682 | 1 | NuMetro Distribution | true | false |
| 16 | 12 | The Blind Side | $14,335 | -60.7% | 26 | -22 | $551 | $1,046,568 | 7 | Warner Bros. | false | false |
| 17 | 15 | Extraordinary Measures | $11,582 | -40.7% | 16 | - | $723 | $50,208 | 2 | Sony Pictures Releasing | false | false |
| 18 | 14 | Alice in Wonderland | $7,636 | -66% | 10 | -14 | $763 | $3,188,348 | 9 | Walt Disney Pictures | false | false |
| 19 | 18 | The Last Station 2010 Re-release | $6,940 | -28.2% | 6 | -3 | $1,156 | $116,059 | 6 | Ster-Kinekor Pictures | false | false |
| 20 | 19 | Shutter Island | $6,452 | -23.7% | 9 | -9 | $716 | $695,719 | 8 | United International Pictures | false | false |
| 21 | 16 | The Hurt Locker | $5,786 | -50% | 10 | -3 | $578 | $316,525 | 6 | NuMetro Distribution | false | false |
| 22 | 17 | It's Complicated | $1,745 | -82.5% | 6 | -14 | $290 | $1,494,284 | 10 | United International Pictures | false | false |
| 23 | - | Jozi | $398 | - | 3 | - | $132 | $109,999 | 10 | United International Pictures | false | false |
| 24 | - | An Education | $365 | - | 1 | - | $365 | $195,624 | 14 | United International Pictures | false | false |
