| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Iron Man 2 | $68,917 | -36.7% | 10 | - | $6,891 | $187,953 | 2 | United International Pictures | false | false |
| 2 | 2 | Clash of the Titans | $45,764 | -34.6% | 9 | - | $5,084 | $419,055 | 4 | Warner Bros. | false | false |
| 3 | - | Date Night | $29,207 | - | 5 | - | $5,841 | $29,207 | 1 | 20th Century Fox International | true | false |
| 4 | 3 | My Name Is Khan | $18,921 | -22.3% | 8 | - | $2,365 | $493,656 | 12 | 20th Century Fox International | false | false |
| 5 | 5 | How to Train Your Dragon | $14,009 | -16.9% | 8 | - | $1,751 | $167,865 | 6 | United International Pictures | false | false |
| 6 | - | Brooklyn's Finest | $12,686 | - | 4 | - | $3,171 | $12,686 | 1 | N/A | true | false |
| 7 | 6 | The Bounty Hunter | $9,900 | -33.8% | 6 | - | $1,650 | $215,095 | 7 | Sony Pictures Releasing | false | false |
| 8 | 4 | Alice in Wonderland | $9,855 | -42.1% | 3 | -1 | $3,285 | $480,620 | 10 | Walt Disney Pictures | false | false |
| 9 | 9 | The Alphabet Killer | $7,018 | -31.9% | 3 | - | $2,339 | $19,661 | 2 | - | false | false |
| 10 | 8 | The Last Song | $5,996 | -41.9% | 3 | - | $1,998 | $37,798 | 3 | Walt Disney Pictures | false | false |
| 11 | 10 | Remember Me | $5,943 | -33.8% | 3 | -2 | $1,981 | $99,631 | 6 | - | false | false |
| 12 | 11 | Shutter Island | $5,349 | -29.6% | 7 | -3 | $764 | $253,469 | 9 | United International Pictures | false | false |
| 13 | 13 | Avatar | $5,298 | -13.5% | 2 | - | $2,649 | $2,271,630 | 21 | 20th Century Fox International | false | false |
| 14 | 7 | New York | $4,583 | -58.3% | 5 | - | $916 | $17,397 | 2 | - | false | false |
| 15 | 12 | Daybreakers | $3,887 | -37.3% | 5 | - | $777 | $27,923 | 3 | N/A | false | false |
| 16 | 14 | From Paris with Love | $3,776 | -27.3% | 6 | -2 | $629 | $174,176 | 9 | N/A | false | false |
| 17 | 17 | Stag Night | $1,641 | -15.5% | 2 | - | $820 | $44,195 | 11 | N/A | false | false |
| 18 | 16 | The Wolfman | $1,555 | -28.8% | 4 | -2 | $388 | $180,839 | 11 | United International Pictures | false | false |
| 19 | 19 | Green Zone | $1,034 | -36.5% | 4 | - | $258 | $120,207 | 8 | United International Pictures | false | false |
| 20 | 18 | Pandorum | $777 | -58.7% | 2 | -1 | $388 | $33,447 | 6 | N/A | false | false |
| 21 | 22 | Valentine's Day | $335 | -45.1% | 1 | - | $335 | $261,047 | 13 | Warner Bros. | false | false |
| 22 | 25 | It's Complicated | $41 | +5.1% | 1 | - | $41 | $122,859 | 14 | United International Pictures | false | false |
| 23 | 23 | The Lovely Bones | $22 | -88.5% | 1 | -1 | $22 | $28,688 | 7 | United International Pictures | false | false |
