| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Clash of the Titans | $439,711 | -18.1% | 93 | +2 | $4,728 | $1,486,868 | 2 | Warner Bros. | false | false |
| 2 | 2 | Date Night | $115,890 | -19.5% | 49 | -3 | $2,365 | $723,664 | 3 | 20th Century Fox International | false | false |
| 3 | - | Paranormal Activity | $63,922 | - | 38 | - | $1,682 | $63,922 | 1 | N/A | true | false |
| 4 | 3 | How to Train Your Dragon | $59,267 | -33.3% | 61 | -5 | $971 | $1,505,696 | 5 | United International Pictures | false | false |
| 5 | 4 | Did You Hear About the Morgans? | $48,027 | -35.9% | 36 | -4 | $1,334 | $188,670 | 2 | Sony Pictures Releasing | false | false |
| 6 | 5 | The Bounty Hunter | $36,355 | -45.8% | 27 | -12 | $1,346 | $604,979 | 4 | Sony Pictures Releasing | false | false |
| 7 | 6 | Alice in Wonderland | $33,128 | -47.9% | 50 | -7 | $662 | $4,227,389 | 8 | Walt Disney Pictures | false | false |
| 8 | - | Dear John | $32,905 | - | 15 | - | $2,193 | $32,905 | 1 | Sony Pictures Releasing | true | false |
| 9 | 8 | Case 39 | $25,224 | -19.9% | 23 | -4 | $1,096 | $185,687 | 3 | United International Pictures | false | false |
| 10 | 7 | The Book of Eli | $22,627 | -55% | 23 | -15 | $983 | $966,364 | 5 | Sony Pictures Releasing | false | false |
| 11 | 9 | The Imaginarium of Doctor Parnassus | $16,700 | -27.8% | 10 | - | $1,670 | $58,239 | 2 | Sony Pictures Releasing | false | false |
| 12 | 10 | I Hate Valentine's Day | $16,642 | -27.7% | 15 | +1 | $1,109 | $65,866 | 2 | N/A | false | false |
| 13 | - | Street Fighter: The Legend of Chun-Li | $11,255 | - | 14 | - | $803 | $11,255 | 1 | N/A | true | false |
| 14 | 14 | Everybody's Fine | $9,046 | +119.7% | 10 | +5 | $904 | $68,532 | 3 | Walt Disney Pictures | false | false |
| 15 | 11 | Couples Retreat | $5,229 | -51.5% | 9 | -5 | $581 | $363,535 | 5 | United International Pictures | false | false |
| 16 | 12 | The Haunting in Connecticut | $3,408 | -67.4% | 7 | -4 | $486 | $257,991 | 5 | N/A | false | false |
| 17 | 13 | 500 Days of Summer | $3,125 | -43% | 3 | -1 | $1,041 | $84,103 | 5 | 20th Century Fox International | false | false |
| 18 | 15 | Old Dogs | $1,977 | -48.7% | 7 | -4 | $282 | $2,466,088 | 12 | United International Pictures | false | false |
| 19 | 16 | The Blind Side | $1,730 | -47.7% | 2 | -2 | $865 | $355,921 | 6 | Warner Bros. | false | false |
| 20 | 21 | Feast 2010 Re-release | $1,534 | -7% | 2 | +1 | $767 | $24,229 | 6 | N/A | false | false |
| 21 | 17 | Shutter Island | $769 | -73.2% | 3 | -3 | $256 | $634,691 | 7 | United International Pictures | false | false |
| 22 | 18 | Desautorizados | $652 | -76.5% | 1 | -5 | $652 | $57,691 | 5 | N/A | false | false |
| 23 | 19 | The Return 2010 Re-release | $323 | -82.7% | 1 | -2 | $323 | $118,651 | 9 | N/A | false | false |
