| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Clash of the Titans | $1,302,156 | - | 186 | - | $7,000 | $1,302,156 | 1 | Warner Bros. | true | false |
| 2 | 3 | Legion | $103,396 | -46.9% | 50 | - | $2,067 | $366,903 | 2 | Sony Pictures Releasing | false | false |
| 3 | 2 | How to Train Your Dragon | $94,055 | -60.9% | 87 | +85 | $1,081 | $1,599,606 | 4 | United International Pictures | false | false |
| 4 | - | It's Complicated | $87,875 | - | 50 | - | $1,757 | $87,875 | 1 | United International Pictures | true | false |
| 5 | 1 | Alice in Wonderland | $69,260 | -75.7% | 93 | -37 | $744 | $6,629,256 | 7 | Walt Disney Pictures | false | false |
| 6 | - | Cell 211 | $48,674 | - | 31 | - | $1,570 | $48,674 | 1 | Cineplex | true | false |
| 7 | 5 | Case 39 | $30,925 | -52.2% | 37 | +2 | $835 | $120,288 | 2 | United International Pictures | false | false |
| 8 | 4 | The Book of Eli | $28,750 | -67.3% | 45 | -30 | $638 | $987,583 | 5 | Sony Pictures Releasing | false | false |
| 9 | 7 | Shutter Island | $13,124 | -55.4% | 23 | -4 | $570 | $453,634 | 6 | United International Pictures | false | false |
| 10 | 6 | The Blind Side | $12,457 | -75.8% | 16 | -27 | $778 | $376,121 | 4 | Warner Bros. | false | false |
| 11 | 10 | Mongol: The Rise of Genghis Khan | $9,744 | -46.7% | 8 | -1 | $1,218 | $37,190 | 2 | Cine Colombia | false | false |
| 12 | - | Smother | $8,782 | - | 10 | - | $878 | $8,782 | 1 | Cine Colombia | true | false |
| 13 | 13 | The Hurt Locker | $3,379 | -46.3% | 9 | -1 | $375 | $248,213 | 10 | Cineplex | false | false |
| 14 | 14 | [Rec]² | $2,927 | -45.3% | 7 | -5 | $418 | $248,193 | 7 | Cine Colombia | false | false |
| 15 | 11 | Remember Me | $2,443 | -83% | 5 | -18 | $488 | $164,224 | 4 | Cine Colombia | false | false |
| 16 | 16 | Old Dogs | $1,921 | -55.2% | 3 | -2 | $640 | $1,186,612 | 15 | Walt Disney Pictures | false | false |
| 17 | 17 | Away We Go | $1,791 | -56.3% | 3 | -2 | $597 | $8,002 | 2 | United International Pictures | false | false |
| 18 | 9 | Did You Hear About the Morgans? | $1,429 | -92.9% | 8 | -35 | $178 | $280,784 | 4 | Sony Pictures Releasing | false | false |
| 19 | 18 | The Anarchist's Wife | $1,133 | -69.7% | 2 | -2 | $566 | $27,591 | 4 | Cineplex | false | false |
| 20 | 19 | Tooth Fairy | $1,037 | -63.6% | 6 | -4 | $172 | $1,135,891 | 13 | 20th Century Fox International | false | false |
| 21 | 12 | Edge of Darkness | $1,011 | -91.5% | 8 | -15 | $126 | $448,286 | 6 | Warner Bros. | false | false |
| 22 | 20 | Couples Retreat | $845 | -68.7% | 3 | -1 | $281 | $222,785 | 8 | United International Pictures | false | false |
| 23 | 25 | A Serious Man | $813 | -9% | 1 | -1 | $813 | $12,595 | 5 | United International Pictures | false | false |
| 24 | - | The Men Who Stare at Goats | $779 | - | 3 | - | $259 | $13,109 | 6 | Sony Pictures Releasing | false | false |
| 25 | 24 | Precious | $725 | -20.1% | 2 | -1 | $362 | $300,173 | 9 | Cine Colombia | false | false |
| 26 | 23 | The White Ribbon | $657 | -48.8% | 1 | -1 | $657 | $34,799 | 7 | - | false | false |
| 27 | 22 | A Prophet | $542 | -68.4% | 1 | -2 | $542 | $15,715 | 5 | Sony Pictures Releasing | false | false |
