| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Clash of the Titans | $752,228 | - | 89 | - | $8,452 | $752,228 | 1 | Warner Bros. | true | false |
| 2 | 1 | Alice in Wonderland | $484,524 | -55.3% | 165 | -2 | $2,936 | $8,062,083 | 5 | Walt Disney Pictures | false | false |
| 3 | 2 | How to Train Your Dragon | $301,334 | -57.6% | 173 | - | $1,741 | $1,553,548 | 2 | Universal Pictures International (UPI) | false | false |
| 4 | 3 | The Bounty Hunter | $248,611 | -44.7% | 51 | - | $4,874 | $858,132 | 2 | Sony Pictures Releasing | false | false |
| 5 | 6 | Remember Me | $154,159 | -31.6% | 67 | +1 | $2,300 | $529,728 | 2 | Independent Films | false | false |
| 6 | 5 | Dear John | $132,457 | -44.4% | 82 | +1 | $1,615 | $1,775,404 | 5 | A-Film Distribution | false | false |
| 7 | 4 | Nanny McPhee Returns | $90,221 | -62.4% | 99 | - | $911 | $724,022 | 3 | Universal Pictures International (UPI) | false | false |
| 8 | 10 | The Girl Who Kicked the Hornet's Nest | $88,660 | -37.9% | 40 | - | $2,216 | $501,723 | 3 | Benelux Film Distributors | false | false |
| 9 | 9 | Shutter Island | $87,660 | -40.9% | 51 | - | $1,718 | $2,561,624 | 8 | Universal Pictures International (UPI) | false | false |
| 10 | 8 | From Paris with Love | $83,361 | -50.8% | 70 | +1 | $1,190 | $905,490 | 4 | Entertainment One | false | false |
| 11 | 7 | Avatar | $79,530 | -56.7% | 31 | -23 | $2,565 | $25,039,680 | 17 | 20th Century Fox International | false | false |
| 12 | 11 | First Mission | $44,645 | -34.2% | 52 | -6 | $858 | $251,812 | 3 | A-Film Distribution | false | false |
| 13 | 12 | The Book of Eli | $30,433 | -52.8% | 30 | -9 | $1,014 | $1,012,045 | 6 | Paradiso Entertainment | false | false |
| 14 | 15 | Nowhere Boy | $28,893 | -37.6% | 13 | - | $2,222 | $103,477 | 2 | A-Film Distribution | false | false |
| 15 | - | Desert Flower 2009 Re-release | $28,593 | - | 18 | - | $1,588 | $38,893 | 1 | Cinéart | true | false |
| 16 | 19 | Case 39 | $24,076 | -39.3% | 14 | -5 | $1,719 | $227,633 | 4 | Universal Pictures International (UPI) | false | false |
| 17 | 13 | Eep! 2010 Re-release | $22,570 | -59.5% | 89 | -1 | $253 | $1,710,569 | 8 | Independent Films | false | false |
| 18 | - | Coco Chanel & Igor Stravinsky | $22,068 | - | 12 | - | $1,839 | $31,065 | 1 | Wild Bunch Distribution | true | false |
| 19 | - | A Single Man | $21,132 | - | 20 | - | $1,056 | $851,485 | 10 | Cinéart | false | false |
| 20 | 16 | The Princess and the Frog | $18,543 | -58.6% | 87 | -8 | $213 | $3,057,126 | 10 | Walt Disney Pictures | false | false |
