| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Life Is a Wonderful Thing | $2,287,044 | - | - | - | - | $2,287,044 | 1 | Medusa Distribuzione | true | false |
| 2 | 1 | How to Train Your Dragon | $1,593,988 | -2.2% | - | - | - | $4,266,470 | 2 | Universal Pictures International (UPI) | false | false |
| 3 | 3 | Happy Family | $1,481,199 | -0.1% | - | - | - | $3,698,729 | 2 | 01 Distribution | false | false |
| 4 | 2 | Alice in Wonderland | $1,210,538 | -22.9% | - | - | - | $39,151,872 | 5 | Walt Disney Pictures | false | false |
| 5 | - | I Love You Phillip Morris | $1,179,991 | - | - | - | - | $1,179,991 | 1 | Lucky Red | true | false |
| 6 | 4 | Loose Cannons | $746,974 | -31.8% | - | - | - | $9,330,207 | 4 | 01 Distribution | false | false |
| 7 | - | Gamer | $670,695 | - | - | - | - | $670,695 | 1 | N/A | true | false |
| 8 | 5 | Remember Me | $640,977 | -38.2% | - | - | - | $2,358,049 | 2 | Eagle Pictures | false | false |
| 9 | 6 | It's Complicated | $605,419 | -35.2% | - | - | - | $4,331,327 | 3 | United International Pictures | false | false |
| 10 | 7 | Shutter Island | $376,011 | -28.3% | - | - | - | $8,958,846 | 5 | Medusa Distribuzione | false | false |
| 11 | - | Little Nicholas | $344,155 | - | - | - | - | $344,155 | 1 | BIM Distribuzione | true | false |
| 12 | - | Sul mare | $296,514 | - | - | - | - | $296,514 | 1 | Warner Bros. | true | false |
| 13 | 9 | Daybreakers | $147,343 | -56.8% | 86 | -60 | $1,713 | $681,640 | 2 | Sony Pictures Releasing | false | false |
| 14 | 16 | Avatar | $129,516 | +58.8% | - | - | - | $87,920,859 | 12 | 20th Century Fox International | false | false |
| 15 | 8 | Percy Jackson & the Olympians: The Lightning Thief | $127,310 | -64.6% | - | - | - | $3,981,794 | 4 | 20th Century Fox International | false | false |
| 16 | 12 | Invictus | $103,125 | -33.7% | - | - | - | $8,306,214 | 6 | Warner Bros. | false | false |
| 17 | 14 | A Prophet | $80,486 | -38.4% | - | - | - | $599,441 | 3 | BIM Distribuzione | false | false |
| 18 | 15 | The Concert | $76,296 | -13.9% | - | - | - | $4,263,277 | 9 | BIM Distribuzione | false | false |
| 19 | 10 | Edge of Darkness | $70,844 | -77.2% | - | - | - | $1,687,325 | 3 | 01 Distribution | false | false |
| 20 | 13 | Genitori & figli:) - Agitare bene prima dell'uso | $56,026 | -61.8% | - | - | - | $11,269,627 | 6 | Filmauro | false | false |
| 21 | 18 | La valigia sul letto | $44,613 | -7.3% | 14 | -6 | $3,186 | $641,636 | 4 | Medusa Distribuzione | false | false |
| 22 | 17 | I Am Love | $34,706 | -52.1% | 22 | -20 | $1,577 | $239,124 | 3 | Mikado Film | false | false |
| 23 | 20 | Women Without Men | $20,678 | -41.9% | 12 | -12 | $1,723 | $338,145 | 4 | BIM Distribuzione | false | false |
| 24 | 11 | Tutto l'amore del mondo | $9,124 | -94.5% | 11 | -152 | $829 | $1,192,420 | 3 | Medusa Distribuzione | false | false |
| 25 | - | Old Dogs | $8,573 | - | 7 | - | $1,224 | $23,802 | 2 | Walt Disney Pictures | false | false |
| 26 | - | Diamond 13 | $8,556 | - | 6 | - | $1,426 | $101,302 | 5 | N/A | false | false |
| 27 | - | Incendiary | $8,289 | - | 6 | - | $1,381 | $122,783 | 6 | N/A | false | false |
| 28 | - | The Man Who Will Come | $7,375 | - | 3 | - | $2,458 | $1,578,190 | 11 | Mikado Film | false | false |
| 29 | - | Crazy Heart | $7,286 | - | 5 | - | $1,457 | $101,693 | 5 | 20th Century Fox International | false | false |
| 30 | - | Legion | $7,024 | - | 3 | - | $2,341 | $810,426 | 4 | Sony Pictures Releasing | false | false |
| 31 | - | The First Beautiful Thing | $6,633 | - | 3 | - | $2,211 | $8,759,030 | 12 | Medusa Distribuzione | false | false |
| 32 | - | Partir | $6,002 | - | 5 | - | $1,200 | $410,506 | 5 | Teodora Film | false | false |
| 33 | - | An Education | $815 | - | 9 | - | $90 | $536,758 | 9 | Sony Pictures Releasing | false | false |
