| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $63,125 | +13.3% | 4 | - | $15,781 | $348,227 | 5 | Walt Disney Pictures | false | false |
| 2 | 2 | The Bounty Hunter | $41,452 | -11.6% | 6 | - | $6,908 | $95,616 | 2 | Sony Pictures Releasing | false | false |
| 3 | 3 | My Name Is Khan | $41,354 | +11.7% | 8 | - | $5,169 | $325,170 | 7 | 20th Century Fox International | false | false |
| 4 | - | How to Train Your Dragon | $37,650 | - | 8 | - | $4,706 | $37,650 | 1 | United International Pictures | true | false |
| 5 | 5 | Avatar | $32,848 | +8.3% | 7 | - | $4,692 | $2,222,816 | 16 | 20th Century Fox International | false | false |
| 6 | 4 | Shutter Island | $29,942 | -6.5% | 10 | - | $2,994 | $182,175 | 4 | United International Pictures | false | false |
| 7 | - | Remember Me | $22,638 | - | 5 | - | $4,527 | $22,638 | 1 | - | true | false |
| 8 | 7 | From Paris with Love | $19,598 | -15.6% | 8 | -2 | $2,449 | $126,002 | 4 | N/A | false | false |
| 9 | 6 | Green Zone | $17,674 | -30.8% | 10 | - | $1,767 | $91,230 | 3 | United International Pictures | false | false |
| 10 | 8 | The Wolfman | $14,446 | +24.5% | 8 | -1 | $1,805 | $151,399 | 6 | United International Pictures | false | false |
| 11 | - | Pandorum | $11,354 | - | 5 | - | $2,270 | $11,354 | 1 | N/A | true | false |
| 12 | 9 | The Lovely Bones | $9,660 | -5% | 8 | - | $1,207 | $21,191 | 2 | United International Pictures | false | false |
| 13 | 10 | Valentine's Day | $8,242 | -8.6% | 4 | - | $2,060 | $252,140 | 8 | Warner Bros. | false | false |
| 14 | 12 | The Children | $7,958 | +10.2% | 3 | -1 | $2,652 | $34,636 | 4 | - | false | false |
| 15 | 14 | The Book of Eli | $5,663 | +49% | 4 | - | $1,415 | $266,167 | 10 | - | false | false |
| 16 | 11 | When in Rome | $5,416 | -26.5% | 3 | -1 | $1,805 | $33,605 | 3 | Walt Disney Pictures | false | false |
| 17 | 17 | Stag Night | $2,172 | +65.5% | 1 | - | $2,172 | $33,525 | 6 | N/A | false | false |
| 18 | 16 | Percy Jackson & the Olympians: The Lightning Thief | $1,420 | -49.1% | 1 | -2 | $1,420 | $107,856 | 8 | 20th Century Fox International | false | false |
| 19 | 13 | It's Complicated | $1,002 | -77.7% | 5 | - | $200 | $121,125 | 9 | United International Pictures | false | false |
| 20 | 19 | The Tournament | $585 | +54.4% | 1 | - | $585 | $18,272 | 5 | - | false | false |
| 21 | 18 | Alvin and the Chipmunks: The Squeakquel | $466 | -5.7% | 1 | - | $466 | $150,489 | 15 | 20th Century Fox International | false | false |
| 22 | 23 | 2012 | $349 | +57.9% | 1 | - | $349 | $1,101,106 | 21 | Sony Pictures Releasing | false | false |
| 23 | 20 | Sherlock Holmes | $333 | +11% | 1 | - | $333 | $396,454 | 14 | Warner Bros. | false | false |
| 24 | 15 | Up in the Air | $272 | -91.8% | 2 | -3 | $136 | $75,863 | 8 | United International Pictures | false | false |
| 25 | 22 | The Princess and the Frog | $67 | -69.8% | 2 | - | $33 | $78,537 | 14 | Walt Disney Pictures | false | false |
| 26 | - | Nine | $36 | - | 1 | - | $36 | $74,434 | 11 | N/A | false | false |
