| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $31,239 | -44.1% | 11 | +2 | $2,839 | $328,487 | 4 | Walt Disney Pictures | false | false |
| 2 | - | How to Train Your Dragon | $25,324 | - | 10 | - | $2,532 | $25,324 | 1 | Paramount Pictures International | true | false |
| 3 | - | The Bounty Hunter | $19,117 | - | 5 | - | $3,823 | $19,117 | 1 | Sony Pictures Releasing | true | false |
| 4 | - | La despedida | $17,569 | - | 5 | - | $3,513 | $17,569 | 1 | N/A | true | false |
| 5 | 2 | The Book of Eli | $15,344 | -28.3% | 5 | - | $3,068 | $43,955 | 2 | Sony Pictures Releasing | false | false |
| 6 | 5 | The Blind Side | $7,166 | -20.2% | 4 | - | $1,791 | $49,848 | 4 | Warner Bros. | false | false |
| 7 | 3 | Avatar | $6,520 | -45.4% | 3 | - | $2,173 | $1,153,942 | 15 | 20th Century Fox International | false | false |
| 8 | 6 | Edge of Darkness | $6,511 | -23.9% | 3 | -2 | $2,170 | $93,722 | 5 | Warner Bros. | false | false |
| 9 | - | Saw VI | $6,221 | - | 5 | - | $1,244 | $6,221 | 1 | Walt Disney Pictures | true | false |
| 10 | 7 | The Widows of Thursdays | $4,559 | -42.4% | 3 | -3 | $1,519 | $54,042 | 4 | N/A | false | false |
| 11 | - | Amelia | $4,253 | - | 2 | - | $2,126 | $4,253 | 1 | 20th Century Fox International | true | false |
| 12 | 8 | Couples Retreat | $3,324 | -57.7% | 3 | -3 | $1,108 | $28,398 | 3 | Universal Pictures International (UPI) | false | false |
| 13 | 13 | Let it Rain | $2,480 | +2.7% | 2 | - | $1,240 | $5,678 | 2 | N/A | false | false |
| 14 | 10 | Two Lovers | $2,469 | -55.1% | 2 | -1 | $1,234 | $10,178 | 2 | N/A | false | false |
| 15 | 4 | The Hurt Locker | $2,407 | -75.6% | 2 | -2 | $1,203 | $80,785 | 8 | N/A | false | false |
| 16 | 9 | Did You Hear About the Morgans? | $2,324 | -64.5% | 3 | -2 | $774 | $73,115 | 5 | Sony Pictures Releasing | false | false |
| 17 | 15 | An Education | $1,982 | +4.3% | 2 | +1 | $991 | $56,743 | 6 | Sony Pictures Releasing | false | false |
| 18 | 14 | A Serious Man | $1,766 | -18.1% | 1 | - | $1,766 | $21,602 | 5 | Universal Pictures International (UPI) | false | false |
| 19 | 11 | Tooth Fairy | $1,629 | -52.7% | 4 | - | $407 | $58,281 | 5 | 20th Century Fox International | false | false |
| 20 | - | Igor | $1,034 | - | 3 | - | $344 | $1,034 | 1 | N/A | true | false |
| 21 | 18 | Alvin and the Chipmunks: The Squeakquel | $235 | -66.6% | 1 | -1 | $235 | $169,028 | 13 | 20th Century Fox International | false | false |
| 22 | 12 | Cirque du Freak: The Vampire's Assistant | $103 | -96.4% | 2 | -3 | $51 | $3,383 | 2 | Universal Pictures International (UPI) | false | false |
