| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $206,347 | -52.7% | 18 | - | $11,463 | $2,123,935 | 3 | Walt Disney Pictures | false | false |
| 2 | - | The Shock Labyrinth 3D | $163,386 | - | 12 | - | $13,615 | $244,073 | 1 | N/A | true | false |
| 3 | 2 | Green Zone | $66,440 | -58% | 7 | -10 | $9,491 | $368,973 | 2 | United International Pictures | false | false |
| 4 | - | The Lovely Bones | $61,503 | - | 15 | - | $4,100 | $76,692 | 1 | United International Pictures | true | false |
| 5 | - | Edge of Darkness | $60,895 | - | 15 | - | $4,059 | $79,396 | 1 | N/A | true | false |
| 6 | 3 | The Hurt Locker | $54,623 | -56.5% | 13 | - | $4,201 | $293,180 | 2 | N/A | false | false |
| 7 | 6 | The Blind Side | $35,977 | -32.3% | 12 | -1 | $2,998 | $436,261 | 4 | Warner Bros. | false | false |
| 8 | 4 | Did You Hear About the Morgans? | $25,154 | -66.2% | 27 | - | $931 | $165,487 | 2 | Sony Pictures Releasing | false | false |
| 9 | 5 | Shutter Island | $24,099 | -55.1% | 11 | -4 | $2,190 | $800,686 | 4 | United International Pictures | false | false |
| 10 | 7 | Up in the Air | $15,288 | -59.5% | 11 | -5 | $1,389 | $232,172 | 3 | United International Pictures | false | false |
| 11 | 8 | Nodame Cantabile: The Movie II | $14,937 | -52.8% | 9 | -2 | $1,659 | $174,177 | 3 | N/A | false | false |
| 12 | 9 | Avatar | $14,141 | -37.3% | 3 | -3 | $4,713 | $13,472,171 | 14 | 20th Century Fox International | false | false |
| 13 | - | 9 | $5,605 | - | 9 | - | $622 | $6,892 | 1 | N/A | true | false |
| 14 | - | A Good Husband | $5,141 | - | 5 | - | $1,028 | $6,504 | 1 | N/A | true | false |
| 15 | 12 | Monga | $2,393 | -65% | 1 | -8 | $2,393 | $3,652,802 | 7 | Warner Bros. | false | false |
| 16 | 11 | Nine | $2,324 | -73% | 1 | -5 | $2,324 | $228,356 | 4 | N/A | false | false |
| 17 | 10 | Brothers | $1,650 | -84.6% | 4 | -5 | $412 | $24,275 | 2 | N/A | false | false |
| 18 | 15 | A Single Man | $531 | -62% | 1 | -2 | $531 | $22,015 | 3 | N/A | false | false |
| 19 | 13 | A Prophet | $452 | -87.6% | 1 | -3 | $452 | $7,607 | 2 | N/A | false | false |
| 20 | 17 | The Road | $25 | -78.4% | 1 | - | $25 | $34,859 | 4 | N/A | false | false |
