| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $22,590 | -33.5% | 6 | - | $3,765 | $139,340 | 3 | Walt Disney Pictures | false | false |
| 2 | - | The Book of Eli | $11,846 | - | 6 | - | $1,974 | $11,846 | 1 | Sony Pictures Releasing | true | false |
| 3 | 2 | Shutter Island | $10,306 | -55.1% | 4 | - | $2,576 | $81,577 | 2 | United International Pictures | false | false |
| 4 | 3 | Avatar | $10,185 | -25.5% | 14 | - | $727 | $1,273,254 | 14 | 20th Century Fox International | false | false |
| 5 | 4 | The Wolfman | $3,100 | -60.8% | 6 | - | $516 | $84,179 | 4 | United International Pictures | false | false |
| 6 | 5 | The Men Who Stare at Goats | $2,842 | -52.6% | 4 | - | $710 | $18,670 | 2 | N/A | false | false |
| 7 | 6 | Percy Jackson & the Olympians: The Lightning Thief | $2,375 | -58.1% | 7 | - | $339 | $36,547 | 4 | 20th Century Fox International | false | false |
| 8 | 12 | The Imaginarium of Doctor Parnassus | $1,985 | +6.8% | 2 | - | $992 | $35,185 | 6 | N/A | false | false |
| 9 | 8 | The Princess and the Frog | $1,830 | -20.6% | 6 | - | $305 | $66,247 | 8 | Walt Disney Pictures | false | false |
| 10 | 7 | Valentine's Day | $1,812 | -58.4% | 6 | - | $302 | $125,168 | 6 | Warner Bros. | false | false |
| 11 | 17 | Arthur and the Revenge of Maltazard | $1,004 | +12.6% | 6 | - | $167 | $62,261 | 12 | N/A | false | false |
| 12 | 9 | Invictus 2010 Re-release | $859 | -62.5% | 4 | - | $214 | $24,916 | 3 | Warner Bros. | false | false |
| 13 | 11 | Alvin and the Chipmunks: The Squeakquel | $720 | -65.2% | 6 | - | $120 | $58,152 | 10 | 20th Century Fox International | false | false |
| 14 | 13 | Sherlock Holmes | $710 | -56.6% | 6 | - | $118 | $222,271 | 11 | Warner Bros. | false | false |
| 15 | 10 | Toy Story 2009 Re-release | $622 | -71.3% | 3 | - | $207 | $29,020 | 6 | Walt Disney Pictures | false | false |
| 16 | 18 | Did You Hear About the Morgans? | $493 | -33.6% | 5 | +1 | $98 | $87,161 | 9 | Sony Pictures Releasing | false | false |
| 17 | 21 | Antichrist | $339 | -23.1% | 1 | - | $339 | $12,454 | 3 | N/A | false | false |
| 18 | 14 | Daybreakers | $322 | -73.8% | 2 | - | $161 | $2,360 | 2 | N/A | false | false |
| 19 | 16 | Nine | $280 | -72% | 4 | - | $70 | $31,115 | 7 | N/A | false | false |
| 20 | 23 | Baaria | $246 | -26.1% | 1 | - | $246 | $14,364 | 2 | N/A | false | false |
| 21 | 27 | Up in the Air | $186 | -24.7% | 5 | - | $37 | $45,197 | 7 | United International Pictures | false | false |
| 22 | 20 | Pope Joan | $184 | -60.4% | 2 | - | $92 | $8,855 | 3 | N/A | false | false |
| 23 | 15 | The Lovely Bones | $180 | -83.1% | 5 | - | $36 | $27,106 | 5 | United International Pictures | false | false |
| 24 | 30 | Old Dogs | $153 | +73.9% | 5 | - | $30 | $73,523 | 10 | Walt Disney Pictures | false | false |
| 25 | 25 | Garfield's Fun Fest | $139 | -51.6% | 2 | - | $69 | $13,798 | 13 | N/A | false | false |
| 26 | 22 | The White Ribbon | $139 | -65.8% | 1 | - | $139 | $13,277 | 5 | N/A | false | false |
| 27 | 29 | The Box | $82 | -47.4% | 2 | - | $41 | $10,217 | 10 | N/A | false | false |
| 28 | 28 | Don't Look Back | $70 | -70.2% | 2 | - | $35 | $13,007 | 4 | N/A | false | false |
| 29 | - | The Countess | $63 | - | 1 | - | $63 | $5,379 | 10 | N/A | false | false |
| 30 | 19 | Law Abiding Citizen | $39 | -93.7% | 5 | - | $7 | $20,766 | 5 | N/A | false | false |
| 31 | 24 | The Flight Before Christmas | $29 | -89.9% | 3 | - | $9 | $13,131 | 15 | N/A | false | false |
