| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $55,860 | -28.4% | 9 | - | $6,206 | $282,823 | 3 | Walt Disney Pictures | false | false |
| 2 | - | The Book of Eli | $21,411 | - | 5 | - | $4,282 | $21,411 | 1 | Sony Pictures Releasing | true | false |
| 3 | 3 | Avatar | $11,938 | -30.2% | 3 | - | $3,979 | $1,143,498 | 14 | 20th Century Fox International | false | false |
| 4 | 2 | The Hurt Locker | $9,877 | -45.2% | 4 | - | $2,469 | $74,770 | 7 | N/A | false | false |
| 5 | 7 | The Blind Side | $8,980 | -17.3% | 4 | - | $2,245 | $39,955 | 3 | Warner Bros. | false | false |
| 6 | 5 | Edge of Darkness | $8,553 | -28.7% | 5 | -2 | $1,710 | $84,189 | 4 | Warner Bros. | false | false |
| 7 | 4 | The Widows of Thursdays | $7,920 | -37.6% | 6 | -1 | $1,320 | $46,773 | 3 | N/A | false | false |
| 8 | 6 | Couples Retreat | $7,865 | -32.8% | 6 | - | $1,310 | $22,977 | 2 | Universal Pictures International (UPI) | false | false |
| 9 | 8 | Did You Hear About the Morgans? | $6,545 | -31.8% | 5 | - | $1,309 | $68,918 | 4 | Sony Pictures Releasing | false | false |
| 10 | - | Two Lovers | $5,498 | - | 3 | - | $1,832 | $5,498 | 1 | N/A | true | false |
| 11 | 10 | Tooth Fairy | $3,447 | -31.8% | 4 | - | $861 | $56,443 | 4 | 20th Century Fox International | false | false |
| 12 | - | Cirque du Freak: The Vampire's Assistant | $2,872 | - | 5 | - | $574 | $2,872 | 1 | Universal Pictures International (UPI) | true | false |
| 13 | - | Let it Rain | $2,414 | - | 2 | - | $1,207 | $2,414 | 1 | N/A | true | false |
| 14 | 11 | A Serious Man | $2,155 | -22% | 1 | - | $2,155 | $19,308 | 4 | Universal Pictures International (UPI) | false | false |
| 15 | 13 | An Education | $1,900 | -23.1% | 1 | -1 | $1,900 | $54,144 | 5 | Sony Pictures Releasing | false | false |
| 16 | 9 | Nine | $1,872 | -68.6% | 2 | -1 | $936 | $21,819 | 3 | Sony Pictures Releasing | false | false |
| 17 | 15 | One Day You'll Understand | $1,056 | -12.4% | 1 | - | $1,056 | $2,579 | 2 | N/A | false | false |
| 18 | 17 | Alvin and the Chipmunks: The Squeakquel | $704 | -20.4% | 2 | - | $352 | $168,778 | 12 | 20th Century Fox International | false | false |
| 19 | 12 | Precious | $575 | -78.2% | 2 | -1 | $287 | $46,212 | 6 | N/A | false | false |
| 20 | 20 | Old Dogs | $110 | +86.4% | 1 | - | $110 | $137,222 | 9 | Walt Disney Pictures | false | false |
