| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $11,168,830 | -30.1% | 533 | - | $20,954 | $34,599,414 | 2 | Walt Disney Pictures | false | false |
| 2 | - | Shutter Island | $3,422,324 | - | 416 | - | $8,226 | $3,422,324 | 1 | Paramount Pictures International | true | false |
| 3 | - | Green Zone | $3,174,704 | - | 419 | - | $7,576 | $3,174,704 | 1 | Universal Pictures International (UPI) | true | false |
| 4 | 2 | Avatar | $971,253 | -29.4% | 271 | -74 | $3,583 | $136,663,494 | 13 | 20th Century Fox International | false | false |
| 5 | - | Hachi: A Dog's Tale | $673,389 | - | 316 | - | $2,130 | $673,389 | 1 | Entertainment Film Distributors | true | false |
| 6 | - | The Girl with the Dragon Tattoo | $575,565 | - | 114 | - | $5,048 | $575,565 | 1 | Momentum Pictures | true | false |
| 7 | 4 | The Lovely Bones | $522,259 | -47.9% | 359 | -66 | $1,454 | $8,951,034 | 4 | Paramount Pictures International | false | false |
| 8 | 3 | The Crazies | $383,807 | -62.4% | 296 | -52 | $1,296 | $4,655,118 | 3 | Paramount Pictures International | false | false |
| 9 | 5 | The Princess and the Frog | $339,369 | -41.3% | 442 | -27 | $767 | $16,369,605 | 5 | Walt Disney Pictures | false | false |
| 10 | 7 | Percy Jackson & the Olympians: The Lightning Thief | $296,976 | -47% | 397 | -45 | $748 | $10,980,217 | 5 | 20th Century Fox International | false | false |
| 11 | 8 | Leap Year | $247,094 | -55.3% | 186 | -123 | $1,328 | $2,740,697 | 3 | Optimum Releasing | false | false |
| 12 | 12 | Crazy Heart | $233,767 | -26.5% | 123 | +7 | $1,900 | $1,241,159 | 4 | 20th Century Fox International | false | false |
| 13 | 6 | From Paris with Love | $173,040 | -69.5% | 193 | -79 | $896 | $2,609,205 | 3 | Warner Bros. | false | false |
| 14 | 10 | A Single Man | $165,110 | -50.3% | 69 | -16 | $2,392 | $4,035,997 | 5 | Icon Film Distribution | false | false |
| 15 | 9 | Valentine's Day | $109,197 | -75.7% | 119 | -230 | $917 | $15,460,467 | 5 | Warner Bros. | false | false |
