| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $53,785 | -21.6% | 4 | - | $13,446 | $216,670 | 3 | Walt Disney Pictures | false | false |
| 2 | - | Green Zone | $41,816 | - | 10 | - | $4,181 | $41,816 | 1 | United International Pictures | true | false |
| 3 | 2 | Shutter Island | $39,778 | -32.8% | 10 | - | $3,977 | $108,703 | 2 | United International Pictures | false | false |
| 4 | 4 | My Name Is Khan | $36,220 | -15.1% | 8 | - | $4,527 | $233,958 | 5 | 20th Century Fox International | false | false |
| 5 | 3 | Avatar | $34,034 | -26.2% | 7 | - | $4,862 | $2,155,906 | 14 | 20th Century Fox International | false | false |
| 6 | 5 | From Paris with Love | $30,112 | -17.3% | 10 | +2 | $3,011 | $73,049 | 2 | N/A | false | false |
| 7 | - | When in Rome | $16,571 | - | 4 | - | $4,142 | $16,571 | 1 | Walt Disney Pictures | true | false |
| 8 | 6 | Valentine's Day | $11,855 | -18.6% | 5 | - | $2,371 | $231,729 | 6 | Warner Bros. | false | false |
| 9 | 7 | The Wolfman | $10,366 | -25.8% | 9 | - | $1,151 | $120,748 | 4 | United International Pictures | false | false |
| 10 | 9 | The Children | $7,097 | -8.6% | 4 | - | $1,774 | $16,554 | 2 | - | false | false |
| 11 | 11 | It's Complicated | $4,833 | -26.8% | 5 | - | $966 | $114,178 | 7 | United International Pictures | false | false |
| 12 | 8 | The Book of Eli | $4,794 | -38.8% | 6 | - | $799 | $255,732 | 8 | - | false | false |
| 13 | 13 | Up in the Air | $3,710 | -19.5% | 5 | - | $742 | $71,322 | 6 | United International Pictures | false | false |
| 14 | 10 | Percy Jackson & the Olympians: The Lightning Thief | $3,521 | -53.7% | 3 | -5 | $1,173 | $102,844 | 6 | 20th Century Fox International | false | false |
| 15 | 12 | Sherlock Holmes | $2,808 | -39.9% | 2 | -2 | $1,404 | $396,180 | 12 | Warner Bros. | false | false |
| 16 | 15 | Stag Night | $1,964 | -31.3% | 2 | - | $982 | $29,004 | 4 | N/A | false | false |
| 17 | 18 | The Princess and the Frog | $1,167 | +22.2% | 3 | +1 | $389 | $78,410 | 12 | Walt Disney Pictures | false | false |
| 18 | 14 | The Tournament | $905 | -73% | 1 | -3 | $905 | $17,027 | 3 | - | false | false |
| 19 | 16 | Alvin and the Chipmunks: The Squeakquel | $512 | -73.2% | 2 | - | $256 | $149,957 | 13 | 20th Century Fox International | false | false |
| 20 | 21 | 2012 | $310 | -9.1% | 1 | - | $310 | $1,100,418 | 19 | Sony Pictures Releasing | false | false |
| 21 | 17 | Old Dogs | $186 | -90.2% | 1 | -2 | $186 | $123,726 | 11 | Walt Disney Pictures | false | false |
| 22 | 23 | The Box | $69 | -44.4% | 1 | - | $69 | $30,904 | 10 | N/A | false | false |
| 23 | 25 | The Ugly Duckling and Me! | $68 | +19.3% | 1 | - | $68 | $5,631 | 7 | N/A | false | false |
| 24 | 24 | Nine | $66 | -45% | 1 | - | $66 | $74,641 | 9 | N/A | false | false |
| 25 | 19 | Did You Hear About the Morgans? | $47 | -92.5% | 1 | - | $47 | $61,743 | 8 | Sony Pictures Releasing | false | false |
