| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Shutter Island | $65,004 | - | 9 | - | $7,222 | $65,004 | 1 | United International Pictures | true | false |
| 2 | 1 | Alice in Wonderland | $50,292 | -12.7% | 14 | - | $3,592 | $129,705 | 2 | Walt Disney Pictures | false | false |
| 3 | 2 | Avatar | $26,953 | -12.2% | 13 | - | $2,073 | $1,583,573 | 13 | 20th Century Fox International | false | false |
| 4 | 3 | The Blind Side | $17,848 | -23.3% | 6 | - | $2,974 | $49,684 | 2 | Warner Bros. | false | false |
| 5 | - | Invictus 2010 Re-release | $14,902 | - | 6 | - | $2,483 | $14,902 | 1 | Warner Bros. | true | false |
| 6 | 5 | Cloudy with a Chance of Meatballs | $12,806 | -12.6% | 16 | +2 | $800 | $133,874 | 6 | Sony Pictures Releasing | false | false |
| 7 | 7 | The Spy Next Door 2010 Re-release | $11,454 | -12.9% | 5 | - | $2,290 | $47,699 | 3 | N/A | false | false |
| 8 | 4 | The Wolfman | $8,273 | -63.3% | 8 | -1 | $1,034 | $137,178 | 4 | United International Pictures | false | false |
| 9 | 6 | The Lovely Bones | $6,769 | -49.5% | 7 | - | $967 | $47,334 | 3 | United International Pictures | false | false |
| 10 | 9 | Dear John | $6,167 | -44.4% | 6 | - | $1,027 | $87,278 | 4 | N/A | false | false |
| 11 | 8 | Edge of Darkness | $5,943 | -47.8% | 5 | - | $1,188 | $47,334 | 3 | N/A | false | false |
| 12 | 13 | Alvin and the Chipmunks: The Squeakquel | $5,201 | -26.8% | 8 | - | $650 | $71,427 | 5 | 20th Century Fox International | false | false |
| 13 | 11 | Valentine's Day | $4,850 | -36.4% | 6 | -2 | $808 | $155,753 | 5 | Warner Bros. | false | false |
| 14 | 12 | Up in the Air | $4,432 | -40.6% | 4 | -3 | $1,108 | $139,985 | 6 | United International Pictures | false | false |
