| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $1,090,642 | -7.8% | 161 | -11 | $6,774 | $2,695,521 | 2 | Walt Disney Pictures | false | false |
| 2 | - | Edge of Darkness | $148,717 | - | 58 | - | $2,564 | $148,717 | 1 | Warner Bros. | true | false |
| 3 | - | Shutter Island | $93,117 | - | 25 | - | $3,724 | $93,117 | 1 | United International Pictures | true | false |
| 4 | 2 | Avatar | $67,427 | -31.6% | 12 | -11 | $5,618 | $13,415,101 | 13 | 20th Century Fox International | false | false |
| 5 | 5 | [Rec]² | $54,403 | -22.2% | 29 | -3 | $1,875 | $148,359 | 2 | Cine Colombia | false | false |
| 6 | 4 | Percy Jackson & the Olympians: The Lightning Thief | $44,889 | -38.8% | 51 | -16 | $880 | $799,381 | 5 | 20th Century Fox International | false | false |
| 7 | 3 | The Wolfman | $36,120 | -59.2% | 38 | -47 | $950 | $1,006,937 | 5 | United International Pictures | false | false |
| 8 | 9 | Couples Retreat | $34,954 | +2.5% | 27 | - | $1,294 | $162,587 | 3 | United International Pictures | false | false |
| 9 | 14 | The Hurt Locker | $31,667 | +114.3% | 13 | +3 | $2,435 | $155,741 | 5 | Cineplex | false | false |
| 10 | 8 | Precious | $30,343 | -27.4% | 17 | -2 | $1,784 | $255,729 | 4 | Cine Colombia | false | false |
| 11 | - | Everybody's Fine | $29,109 | - | 17 | - | $1,712 | $29,109 | 1 | Walt Disney Pictures | true | false |
| 12 | 7 | Tooth Fairy | $27,114 | -44.2% | 36 | -10 | $753 | $1,090,314 | 8 | 20th Century Fox International | false | false |
| 13 | 12 | Invictus | $17,658 | -23.2% | 19 | -7 | $929 | $363,053 | 6 | Warner Bros. | false | false |
| 14 | 10 | Valentine's Day | $16,429 | -49.4% | 20 | -8 | $821 | $388,237 | 5 | Warner Bros. | false | false |
| 15 | 16 | Cirque du Freak: The Vampire's Assistant | $13,230 | +11.4% | 9 | -14 | $1,470 | $128,287 | 4 | United International Pictures | false | false |
| 16 | 11 | The Imaginarium of Doctor Parnassus | $12,724 | -47.6% | 9 | - | $1,413 | $44,016 | 2 | Sony Pictures Releasing | false | false |
| 17 | 13 | Old Dogs | $7,413 | -52.8% | 16 | -9 | $463 | $1,157,322 | 10 | Walt Disney Pictures | false | false |
| 18 | 18 | The White Ribbon | $7,109 | -6.2% | 3 | -3 | $2,369 | $17,949 | 2 | - | false | false |
| 19 | 15 | The Lovely Bones | $6,976 | -44.3% | 15 | -10 | $465 | $106,996 | 4 | United International Pictures | false | false |
| 20 | - | The Men Who Stare at Goats | $4,828 | - | 3 | - | $1,609 | $4,828 | 1 | Sony Pictures Releasing | true | false |
| 21 | 21 | Ninja Assassin | $3,028 | +3.9% | 7 | +3 | $432 | $144,048 | 7 | Warner Bros. | false | false |
| 22 | 17 | An Education | $2,753 | -68.9% | 6 | - | $458 | $48,996 | 4 | Sony Pictures Releasing | false | false |
| 23 | 6 | Law Abiding Citizen | $2,495 | -95.4% | 29 | -22 | $86 | $239,077 | 3 | Cineplex | false | false |
| 24 | 20 | Broken Embraces | $1,217 | -65.6% | 3 | -4 | $405 | $102,410 | 6 | United International Pictures | false | false |
| 25 | 19 | The Soloist | $1,131 | -68.4% | 6 | +1 | $188 | $67,395 | 9 | United International Pictures | false | false |
| 26 | 22 | Up in the Air | $1,131 | -56.6% | 1 | -5 | $1,131 | $251,463 | 8 | United International Pictures | false | false |
| 27 | 31 | The Stepfather | $1,123 | +72% | 1 | - | $1,123 | $99,192 | 14 | Sony Pictures Releasing | false | false |
| 28 | 26 | Departures | $1,027 | -45.3% | 1 | -4 | $1,027 | $113,923 | 9 | Cine Colombia | false | false |
| 29 | 23 | Alvin and the Chipmunks: The Squeakquel | $931 | -63.4% | 7 | -3 | $133 | $1,399,523 | 11 | 20th Century Fox International | false | false |
| 30 | 30 | Toy Story 2 2009 Re-release | $633 | -9.7% | 1 | -1 | $633 | $219,923 | 3 | Walt Disney Pictures | false | false |
| 31 | 29 | The Princess and the Frog | $477 | -49.1% | 4 | -2 | $119 | $1,872,829 | 12 | Walt Disney Pictures | false | false |
