| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $83,178 | +37.6% | 32 | +6 | $2,599 | $10,005,437 | 13 | 20th Century Fox International | false | false |
| 2 | 6 | The Hurt Locker | $53,971 | +167.4% | 18 | +7 | $2,998 | $168,270 | 4 | N/A | false | false |
| 3 | 2 | Percy Jackson & the Olympians: The Lightning Thief | $45,016 | -18.8% | 28 | +3 | $1,607 | $647,621 | 5 | 20th Century Fox International | false | false |
| 4 | 3 | The Wolfman | $36,435 | -23.2% | 25 | +6 | $1,457 | $653,438 | 5 | United International Pictures | false | false |
| 5 | 4 | Alvin and the Chipmunks: The Squeakquel | $33,248 | -0.7% | 25 | +5 | $1,329 | $1,319,041 | 7 | 20th Century Fox International | false | false |
| 6 | - | 500 Days of Summer | $23,236 | - | 7 | - | $3,319 | $23,236 | 1 | 20th Century Fox International | true | false |
| 7 | - | Halloween II | $22,718 | - | 16 | - | $1,419 | $22,718 | 1 | N/A | true | false |
| 8 | 5 | The Lovely Bones | $18,137 | -29.8% | 18 | +4 | $1,007 | $203,989 | 4 | United International Pictures | false | false |
| 9 | 8 | Valentine's Day | $10,031 | -25.1% | 14 | +2 | $716 | $295,392 | 5 | Warner Bros. | false | false |
| 10 | 13 | Precious | $9,624 | +23.7% | 4 | +2 | $2,406 | $26,080 | 3 | N/A | false | false |
| 11 | 7 | Couples Retreat | $7,833 | -44.8% | 13 | +2 | $602 | $41,955 | 3 | United International Pictures | false | false |
| 12 | 12 | The Haunting in Connecticut | $7,163 | -8.5% | 6 | +1 | $1,193 | $158,283 | 9 | Transeuropa | false | false |
| 13 | - | Welcome to the Sticks | $7,119 | - | 6 | - | $1,186 | $7,119 | 1 | N/A | true | false |
| 14 | 10 | Ponyo | $6,938 | -22.1% | 8 | - | $867 | $24,324 | 3 | Andes Films | false | false |
| 15 | 9 | Sherlock Holmes | $6,583 | -43.8% | 9 | -2 | $731 | $1,251,720 | 8 | Warner Bros. | false | false |
| 16 | 14 | It's Complicated | $5,023 | +13.4% | 4 | +2 | $1,255 | $240,666 | 7 | United International Pictures | false | false |
| 17 | 11 | Everybody's Fine | $3,662 | -57.7% | 8 | +1 | $457 | $24,539 | 3 | Walt Disney Pictures | false | false |
| 18 | 16 | Nine | $3,576 | +22.8% | 6 | -1 | $596 | $42,866 | 4 | Sony Pictures Releasing | false | false |
| 19 | 17 | Up in the Air | $3,242 | +64.7% | 3 | - | $1,080 | $137,991 | 6 | United International Pictures | false | false |
| 20 | 18 | Toy Story 2009 Re-release | $2,835 | +71.9% | 5 | +4 | $567 | $30,800 | 4 | Walt Disney Pictures | false | false |
| 21 | 19 | Toy Story 2 2009 Re-release | $2,295 | +134.7% | 5 | +4 | $459 | $37,753 | 4 | Walt Disney Pictures | false | false |
| 22 | 15 | Invictus | $1,394 | -63.4% | 2 | -4 | $697 | $192,729 | 6 | Warner Bros. | false | false |
| 23 | 22 | Astro Boy | $956 | +59.9% | 10 | +9 | $95 | $185,589 | 8 | N/A | false | false |
| 24 | 20 | Tooth Fairy | $667 | -15.9% | 1 | - | $667 | $524,523 | 10 | 20th Century Fox International | false | false |
| 25 | 26 | The Imaginarium of Doctor Parnassus | $586 | +118.7% | 2 | +1 | $293 | $79,541 | 7 | Sony Pictures Releasing | false | false |
| 26 | 21 | Igor | $422 | -32.6% | 2 | - | $211 | $21,892 | 5 | N/A | false | false |
| 27 | 24 | Old Dogs | $262 | -21.1% | 1 | - | $262 | $360,864 | 12 | Walt Disney Pictures | false | false |
| 28 | 27 | Saw VI | $149 | -38.2% | 1 | - | $149 | $174,417 | 8 | Walt Disney Pictures | false | false |
